{"id":29304,"date":"2017-04-21T15:03:21","date_gmt":"2017-04-21T14:03:21","guid":{"rendered":"https:\/\/bioengineer.org\/aliver-an-eu-funded-project-to-develop-a-liver-dialysis-machine-revealed-at-ilc-2017\/"},"modified":"2017-04-21T15:03:21","modified_gmt":"2017-04-21T14:03:21","slug":"aliver-an-eu-funded-project-to-develop-a-liver-dialysis-machine-revealed-at-ilc-2017","status":"publish","type":"post","link":"https:\/\/bioengineer.org\/aliver-an-eu-funded-project-to-develop-a-liver-dialysis-machine-revealed-at-ilc-2017\/","title":{"rendered":"ALIVER — an EU funded project to develop a liver dialysis machine revealed at ILC 2017"},"content":{"rendered":"

April 21, 2017, Amsterdam, The Netherlands: The European Association for the Study of the Liver (EASL) today announced that ALIVER will be unveiled at The International Liver Congress\u2122 in Amsterdam, The Netherlands. The \u20ac7.8 million project is funded by the EU Horizon 2020 research programme. Work started on ALIVER on 1 January 2017 and will end on 30 September 2020.<\/p>\n

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Background<\/p>\n

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Each year over 170,000 people die from liver cirrhosis in Europe.1 There are over 1 million deaths globally. 29 million EU citizens and 650 million people globally suffer from a chronic liver disease. The economic burden of liver disease in Europe has been estimated at over \u20ac15.8 billion per annum.2 <\/p>\n

The causes of liver disease are complex, but current rates of obesity and other lifestyle factors will lead to increasing rates of liver failure in coming years. The only treatment that will ensure long term survival and quality of life is a liver transplant. Despite efforts made across Europe to increase organ donation, the number of patients requiring a liver transplant is increasing and supply is not keeping up with demand. There are currently over 1,500 patients on the Eurotransplant waiting list for a new liver,3 and many more in other countries of the EU who are not members of the Eurotransplant network.<\/p>\n

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The response<\/p>\n

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The ALIVER Consortium has developed a novel and innovative liver dialysis machine that will help the liver to naturally regenerate or, where that does not prove possible, to keep patients alive and healthy until a donated liver becomes available. DIALIVE has been demonstrated to be effective in pre-clinical tests. <\/p>\n

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How is DIALIVE different? <\/p>\n

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DIALIVE removes dysfunctional albumin and endotoxins, infuses fresh, functional albumin and specifically targets systemic inflammation using commercially available CE-marked filters in one unit. Existing liver dialysis machines do not restore albumin function, have only a limited effect on systemic inflammation and do not improve survival rates.<\/p>\n

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What happens next?<\/p>\n

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The DIALIVE machine will be tested in clinical settings in the UK, Germany, France and Spain over the course of the project. The ALIVER Consortium believes that DIALIVE will: <\/p>\n