{"id":10065,"date":"2016-10-05T20:24:57","date_gmt":"2016-10-05T19:24:57","guid":{"rendered":"https:\/\/bioengineer.org\/neural-membranes-structural-instability-may-trigger-multiple-sclerosis\/"},"modified":"2016-10-05T20:25:13","modified_gmt":"2016-10-05T19:25:13","slug":"neural-membranes-structural-instability-may-trigger-multiple-sclerosis","status":"publish","type":"post","link":"https:\/\/bioengineer.org\/neural-membranes-structural-instability-may-trigger-multiple-sclerosis\/","title":{"rendered":"Neural membrane\u2019s structural instability may trigger multiple sclerosis"},"content":{"rendered":"

Multiple sclerosis is one of the most devastating neurodegenerative diseases. It affects some 2.5 million people worldwide. It has no known cure.<\/p>\n

\"Credit:
Credit: Tel Aviv University<\/figcaption><\/figure>\n

Until now, researchers have speculated that the body\u2019s own immune system was unleashing an uncontrolled attack on myelin sheaths \u2014 our neurons\u2019 protective shield \u2014 that was largely responsible for the sudden outbreak of the disease.<\/p>\n

But a new Tel Aviv University study published in the Journal of the American Chemical Society (JACS) pinpoints a structural instability in the myelin membranes, the \u201cinsulating tape\u201d surrounding neurons. This vulnerability affords the immune system \u2014 and its attacks \u2014 access to otherwise protected regions.<\/p>\n

\u201cWe found that small modifications in the myelin sheaths create structural instabilities that may help the immune system to enter and attack neurons,\u201d said Prof. Roy Beck, the study\u2019s principal investigator, of TAU\u2019s School of Physics and Astronomy and Sagol School of Neurosciences. \u201cCurrent therapeutic approaches have focused on the autoimmune response without identifying a clear mechanism. Our research suggests a new avenue for multiple sclerosis therapies and diagnostics.\u201d<\/p>\n

Breaking down the insulation<\/p>\n

Our axons, which carry electrical impulses in neurons, are surrounded by protective myelin sheaths. In multiple sclerosis, an autoimmune catastrophe, these sheaths break down and are misidentified as hostile foreign entities, which the immune system then attacks.<\/p>\n

The research, conducted by Rona Shaharabani, a doctoral student in Prof. Beck\u2019s lab, pinpoints the precise alterations to the myelin sheaths that result in structural instabilities, creating \u201ceasy access\u201d for autoimmune attacks. \u201cAfter years of research, we were amazed to discover that a possible trigger for the outbreak of the disease could be found in the membrane\u2019s physical structure,\u201d said Prof. Beck.<\/p>\n

According to Prof. Beck, the lipid are the main building blocks of the myelin sheaths. As such their shape has a critical impact on the resulting self-assembled membrane structure. \u201cIf the basic building blocks are straight, the membrane will be flat, which is the preferred structure for a neuron\u2019s \u2018insulating tape,'\u201d said Prof. Beck. \u201cHowever, if they exhibit a more cone-like shape, the membrane will tend to form closed round cylinders. These produce spontaneous holes in the surface of the sheath, rendering it vulnerable to attack.\u201d<\/p>\n

For the purpose of the research, the scientists harnessed X-ray light to examine hundreds of membrane model systems that mimicked those of healthy and diseased animal models. In collaboration with Prof. Ruth Arnon of the Weizmann Institute, co-developer of the leading MS drug Copaxone\u00ae, and Prof. Yeshayahu Talmon of the Technion \u2013 Israel Institute of Technology, the team also used electron microscopy to determine the different nanoscopic structures of both natural myelin sheaths and model system membranes.<\/p>\n

\u201cThe next step is to find a way to reverse the disease progression and find new techniques for early detection,\u201d said Prof. Beck.<\/p>\n

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Tel Aviv University (TAU) is inherently linked to the cultural, scientific and entrepreneurial mecca it represents. It is one of the world\u2019s most dynamic research centers and Israel\u2019s most distinguished learning environment. Its unique-in-Israel multidisciplinary environment is highly coveted by young researchers and scholars returning to Israel from post-docs and junior faculty positions in the US.<\/p>\n

American Friends of Tel Aviv University (AFTAU) enthusiastically and industriously pursues the advancement of TAU in the US, raising money, awareness and influence through international alliances that are vital to the future of this already impressive institution.<\/p>\n

Media Contact<\/strong><\/p>\n

George Hunka
ghunka@aftau.org
212-742-9070
@AFTAUnews<\/p>\n

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