• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Tuesday, March 9, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Unravelling the origins of autoimmune psychosis

Bioengineer by Bioengineer
October 29, 2020
in Chemistry
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

A first step towards potential treatments

IMAGE

Credit: UNIVERSITY OF BARCELONA

Anti-NMDAR encephalitis is an autoimmune brain illness that is often mistaken by a psychiatric disorder since it causes psychoses and other behaviour alterations. Despite having these similarities, the illness does not respond to common antipsychotic treatments.

A new study by the University of Barcelona (UB) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) shows these symptoms would be caused by alterations in the quantity of dopaminergic receptors D1R and D2R in the hippocampal area of the brain. These results, published in the journal Annals of Neurology, shed light on the biological base of psychotic symptoms in this and other autoimmune psychoses and they could ease the development of new drugs in the future.

The study results from the bachelor’s degree final project of the former student of the Faculty of Medicine and Health Sciences of the UB Marc Carceles-Cordon and it is co-led by Josep Dalmau, ICREA professor, director of the Program on Clinical and Experimental Neuroimmunology at IDIBAPS-Hospital Clínic and UB, and lecturer of Neurology at the University of Pennsylvania (Philadelphia, United States) and Jesús Planagumà, researcher at IDIBAPS. Other participants in the study are the UB and IDIBAPS researchers Francesco Mannara, Esther Aguilar and Aida Castellanos.

Schizophrenia-like symptoms

The objective of the study was to improve the understanding of the molecular origins of the psychotic symptoms in anti-NMDAR encephalitis, the most representative example for autoimmune encephalitis. These are a series of inflammatory brain diseases caused due to the generation of antibodies that attack proteins found in the surface of the neurons of the affected patients. In this illness, found by Professor Dalmau in 2007, the antibodies affect the NMDA receptor, one of the most important ones in synaptic transmission, causing alterations in behaviour and neuropsychiatric symptoms that are similar to those from schizophrenia. Given these similarities, researchers considered the hypothesis that there could be a converging mechanism between autoimmune psychosis and this psychiatric disorder. “Since the dopaminergic system of schizophrenia is altered, we focused on the analysis of the levels of dopaminergic receptors in cell cultures and in one animal model of anti-NMDAR encephalitis”, notes Marc Carceles-Cordon.

This model, carried out by the research group of the UB, administers mice the cerebrospinal fluid that contains pathological antibodies from patients with anti-NMDAR encephalitis. Then, mice develop similar symptoms to those seen in patients, which are molecularly correlated to what occurs in the brain of those affected. The new study adopted the pre-existing model, which has been used successfully in other projefcts, to study psychotic symptoms in depth.

A first step towards potential treatments

The results show that giving cerebrospinal fluid from patients with anti-NMDAR encephalitis produces several changes in the levels of D1r and D2R in neuron brain cultures and similar alterations in the animal model of the disease. These changes cause memory deficits and psychotic behaviour in mice. Last, they observed that all of this reverts when stopping the administration of antibodies to patients.

According to the researchers, these results help understand the biological base of the psychiatric symptoms of anti-NMDAR encephalitis, and the autoimmune psychosis, with important implications in the design of new treatments. “In the future, these data can provide us with the development of antipsychotic drugs that consider the molecular base of this symptom and are more efficient than current antipsychotics -which have been used for decades-, which are not useful and can even be counter-productive when trying to control psychotic symptoms of anti-NMDAR encephalitis”, notes Marc Carceles Cordon.

Moreover, the study can help understand other types of psychosis, a symptom that affects different mental disorders. “For a long time, we regarded this symptom as a part of schizophrenia, but psychosis is present in many mental illnesses (depression, dementia, etc.), and understanding its underlaying mechanisms can, in the future, guide treatments aimed at reducing the pain of the patients”, concludes the researcher.

###

Media Contact
Rosa Martínez
[email protected]

Original Source

https://doi.org/10.1002/ana.25829

Related Journal Article

http://dx.doi.org/10.1002/ana.25829

Tags: BehaviorDiagnosticsDisease in the Developing WorldImmunology/Allergies/AsthmaMedicine/HealthMental HealthneurobiologyPharmaceutical ChemistryPharmaceutical Science
Share12Tweet7Share2ShareShareShare1

Related Posts

IMAGE

Research pinpoints unique drug target in antibiotic resistant bacteria

March 8, 2021
IMAGE

How fast is the universe expanding? Galaxies provide one answer.

March 8, 2021

Lights on for silicon photonics

March 8, 2021

Cheap, nontoxic carbon nanodots poised to be quantum dots of the future

March 8, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    703 shares
    Share 281 Tweet 176
  • People living with HIV face premature heart disease and barriers to care

    86 shares
    Share 34 Tweet 22
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    36 shares
    Share 14 Tweet 9
  • Global analysis suggests COVID-19 is seasonal

    39 shares
    Share 16 Tweet 10

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Chemistry/Physics/Materials SciencesInfectious/Emerging DiseasesGeneticsTechnology/Engineering/Computer SciencecancerPublic HealthMedicine/HealthEcology/EnvironmentBiologyCell BiologyMaterialsClimate Change

Recent Posts

  • Research pinpoints unique drug target in antibiotic resistant bacteria
  • How fast is the universe expanding? Galaxies provide one answer.
  • Young white-tailed deer that disperse survive the same as those that stay home
  • Complement inhibition reverses mental losses in preclinical traumatic brain injury models
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In