The University of Vermont Cancer Center will offer a novel, highly effective form of cancer treatment called CAR T-cell therapy beginning in February, when final accreditation and approval to begin treating patients is expected.
Credit: Andy Duback
The University of Vermont Cancer Center will offer a novel, highly effective form of cancer treatment called CAR T-cell therapy beginning in February, when final accreditation and approval to begin treating patients is expected.
The Cancer Center will be the only healthcare institution in Vermont and northern New York to provide the treatment.
CAR T, as it is known, uses the body’s immune system to fight cancer. Unlike other immunotherapies, CAR T uses genetically modified T cells from the patient to attack cancer cells.
Approved by the FDA in 2017 for a variety of blood cancers, CAR T-cell therapy induces a “complete response” — where no remaining cancer is detectable — in 50-80% of patients treated with it, depending on the cancer type, including in 70% of patients with mantle cell lymphoma and 80% with follicular lymphoma. Up to ninety percent of patients with these two cancers see a “partial response,” where the cancer has been significantly diminished. The therapy is typically used after other forms of treatment have been unsuccessful.
Blood cancers account for 10% of all cancer diagnosed in the United States every year, according to the Leukemia and Lymphoma Society.
Though long-term data for CAR T-cell therapy is not yet available, the treatment has the potential to cure cancer. Of the first patients treated over 10 years ago with CAR T-cell therapy in clinical trials, few of those who achieved a complete response have seen their cancer return.
UVM Clinic Led by One of First Clinicians to Administer CAR T
The Cancer Center’s new CAR T program will be led by James Gerson, M.D., assistant professor in the Larner College of Medicine’s Department of Medicine, who came to UVM from the University of Pennsylvania, where CAR T-cell therapy was discovered and developed.
Gerson worked directly with the team of researchers who created the therapy, led by Carl H. June, M.D., and was among the first in the country to use it in a clinical setting.
“We are thrilled to have someone of Dr. Gerson’s caliber directing our CAR T clinic and offering this life-saving therapy to patients in our region,” said Randall Holcombe, M.D., M.B.A., associate dean for Cancer Programs at the UVM Larner College of Medicine and director of the UVM Cancer Center.
The new CAR T program highlights the benefits that an academic medical center like the UVM Medical Center — which combines cutting edge clinical care and innovative research — can bring to a community.
“The Larner College of Medicine was honored to work with our partners at UVM Medical Center to recruit Dr. Gerson to our academic medical center,” said Richard L. Page, M.D., dean of the Larner College of Medicine. “The CAR T program is yet another example of the profound value that the UVM Cancer Center brings to our region,” he said.
Avoiding Upheaval in Patients’ Lives
Currently, patients in UVMMC’s catchment area who want CAR T therapy need to travel, usually to Boston, New York, Dartmouth or Rochester, to access it.
The remote treatment can cause significant upheaval in their lives, Gerson said, since it requires multiple episodes of care over the course of three to six months. Many patients live in the area where they’re being treated for four weeks.
“Our goal is for you to be able to access this therapy without uprooting your life,” he said.
CAR T works by training T cells — a type of white blood cell used by the immune system to kill viruses and other foreign bodies — to recognize and attack cancer cells.
The treatment has several steps. First, T cells are removed from the patient’s blood. Then, in the lab, they’re modified by adding a receptor gene — a “chimeric antigen receptor” or CAR — that can recognize a protein on the cancer cell, latch onto it and kill the cell. Finally, cells are multiplied and given back to the patient.
CAR T is currently approved only for blood cancers: lymphoma, some leukemias, and multiple myeloma. Research is ongoing to apply the method to other cancers.
“We look forward to bringing this innovative new treatment to the patients who need it in our region. I’ve seen first-hand its potential to save lives,” Gerson said.