• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, June 18, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Treatment shown to improve the odds against bone marrow cancer

Bioengineer by Bioengineer
December 16, 2018
in Health
Reading Time: 4 mins read
0
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Hope has emerged for patients with a serious type of bone marrow cancer as new research into a therapeutic drug has revealed improved outcomes and survival rates.

In the largest study of its kind, researchers at Newcastle University, UK, have led national research into the treatment of patients with newly diagnosed myeloma.

The results, published online today by The Lancet Oncology, show an improvement for those who received ongoing therapy with a drug called lenalidomide, compared to those not receiving it.

Improved outcomes

Findings of the study identified that long-term therapy with lenalidomide (also known as Revlimid®) doubles remission duration and also improves survival in younger patients by almost 8%.

Myeloma is a cancer of the plasma cells and it can affect several areas of the body, such as the spine, skull, pelvis and ribs. Current treatment usually involves chemotherapy and a stem-cell transplant.

Professor Graham Jackson, from the Northern Institute for Cancer Research at Newcastle University, and a Consultant Haematologist at Newcastle’s Freeman Hospital, led the UK-wide study.

He said: “This is a major breakthrough as it shows that the long-term use of lenalidomide significantly improves the time myeloma patients stay in remission after initial therapy.

“It is a huge step and, importantly, identifies that for younger patients lenalidomide improves their overall survival for this difficult-to-treat bone marrow cancer.

“Our research highlights that lenalidomide should be considered for newly diagnosed patients following stem-cell transplantation.”

Study’s findings

The Myeloma XI seven-year study involved more than 4,000 patients in 110 hospitals in the UK and was funded primarily by Cancer Research UK, with support from Myeloma UK and a number of educational grants.

As part of the study, a total of 1,137 newly diagnosed patients were randomly assigned to lenalidomide maintenance therapy and 834 patients to observation – this was after they completed their initial treatment.

The results show that lenalidomide can prolong the average remission time by more than two years in younger patients and by well over a year in older, less fit patients. It reduced the risk of progression or death by more than 50% in both groups.

The trial was run through the Clinical Trials Research Unit at the University of Leeds and the research involved experts from hospitals around the UK.

Professor Gordon Cook, Clinical Director at the Leeds Institute of Clinical Trials Research at the University of Leeds, was a co-author of the paper and believes lenalidomide should be available on the NHS.

He said: “Our results confirm lenalidomide can significantly prolong the lives of people living with myeloma in the largest trial to date.

“This treatment is not yet available on the NHS for this group of patients and this represents an unmet need.”

The results confirm the findings of three much smaller studies which showed that after stem-cell transplantation, lenalidomide reduces the risk of disease progression or death by 50% compared with placebo or no treatment.

Patient’s story

Mother-of-one Sarah Williamson was given a shock diagnosis of myeloma three years ago.

The 41-year-old had suffered from back and shoulder pain for almost a year but believed it was a running injury and could never have imagined how her life would be turned upside down.

She had attended her doctors’ surgery multiple times, but it was not until a birthday hug from her husband fractured a rib, and she was unable to get out of bed one morning, that the seriousness of her condition became clear.

Hospital scans and tests revealed that she had myeloma and Sarah was put under the care of Professor Graham Jackson at the Freeman Hospital.

She joined the Myeloma XI study and was randomly selected to receive lenalidomide following chemotherapy and a stem-cell transplant.

Sarah, who is married to Richard, 39, and has daughter, Annecy, six, is currently in remission and has no sign of the bone marrow cancer in her body.

The communications executive, from Darlington, said: “It was devastating to be diagnosed with myeloma. I had a young child, my health was in a bad way and I couldn’t imagine feeling well again.

“When I was asked if I wanted to be part of the clinical trial I didn’t hesitate to say ‘yes’ and I was delighted that I was randomly selected to get lenalidomide as I’ve responded very well to the drug.

“For patients to get an extra two years remission is fantastic and it’s what every person with the condition hopes for as it means they can get their life back to as normal as possible.

“I have hardly any side effects of the treatment and all my pain is gone. I feel lenalidomide should be available on the NHS.

“When I meet people who have the condition and are not on the trial I feel a sense of injustice on their behalf as taking this drug has helped me get my life back and I am enjoying it to the full.”

Sarah continues to be monitored by experts and gets regular check-ups and medical tests.

###

Reference

Lenalidomide maintenance versus observation for patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-lab, randomised, phase 3 trial

Graham H Jackson et al.

The Lancet Oncology. DOI: 10.1016/S1470-2045

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30687-9/fulltext

Media Contact
Helen Rae
[email protected]
44-019-120-87374
http://dx.doi.org/10.1016/S1470-2045

Tags: cancerClinical TrialsDeath/DyingDiagnosticsHealth Care Systems/ServicesHematologyMedicine/HealthMortality/LongevityPain
Share12Tweet8Share2ShareShareShare2

Related Posts

Imaging Breakthroughs Reveal Early Parkinson’s Signs

Imaging Breakthroughs Reveal Early Parkinson’s Signs

June 18, 2025
Sublattice Reconstruction Boosts Optical Nonlinearities 500x

Sublattice Reconstruction Boosts Optical Nonlinearities 500x

June 18, 2025

Measuring Vinyl Acetate Exposure from Consumer Products

June 18, 2025

Heat Shock Proteins Signal Neuron-Glia Aging Talk

June 18, 2025
Please login to join discussion

POPULAR NEWS

  • Green brake lights in the front could reduce accidents

    Study from TU Graz Reveals Front Brake Lights Could Drastically Diminish Road Accident Rates

    161 shares
    Share 64 Tweet 40
  • New Study Uncovers Unexpected Side Effects of High-Dose Radiation Therapy

    76 shares
    Share 30 Tweet 19
  • Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    71 shares
    Share 28 Tweet 18
  • How Scientists Unraveled the Mystery Behind the Gigantic Size of Extinct Ground Sloths—and What Led to Their Demise

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Imaging Breakthroughs Reveal Early Parkinson’s Signs

Navigating New Frontiers: ESG Lending and Tech Investments Propel Stability and Growth in BRICS Banks

Breakthrough in 30-Year Micronutrient Mystery Paves Way for Innovative Medical Research

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.