• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Monday, May 23, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Treating rheumatoid arthritis with micromotors

Bioengineer by Bioengineer
February 24, 2021
in Biology
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Adapted from Nano Letters 2021, DOI: 10.1021/acs.nanolett.0c04438

Rheumatoid arthritis is a chronic inflammatory disorder marked by joint pain, swelling and damage. Although medications, such as steroids, anti-inflammatory drugs and immunosuppressants, can help slow joint destruction and relieve pain, they have side effects and aren’t completely successful. Now, researchers reporting in ACS’ Nano Letters have developed magnesium-based micromotors propelled by hydrogen bubbles, which improved rheumatoid arthritis symptoms when injected into the joints of rats.

Scientists have linked rheumatoid arthritis development to the excess production of reactive oxygen species (ROS). ROS can oxidize and degrade cartilage and bone, as well as activate the expression of inflammatory cytokines. A new type of therapy, hydrogen gas, can neutralize ROS and decrease inflammatory cytokine levels when given to patients in drinking water. However, the gas is poorly soluble in body fluids and quickly eliminated when given orally, limiting its therapeutic effects. Fei Peng, Yingfeng Tu, Yingjia Li and colleagues wanted to find a way to produce and deliver hydrogen gas directly inside an inflamed joint.

The researchers based their system on magnesium-based micromotors — tiny spheres that react with water to produce hydrogen bubbles, which propel the motors. They coated the micromotors with hyaluronic acid, a joint lubricant, leaving a small opening for the magnesium to react with water. When placed in simulated joint fluid, the micromotors showed prolonged, sustained release of hydrogen bubbles and could move on their own. The team then injected the micromotors into the joints of rats that served as an animal model of rheumatoid arthritis and used ultrasound to visualize them. Compared with uninjected rats, the treated rats showed less-swollen paws, reduced bone erosion and lower levels of inflammatory cytokines. Although the micromotors still need to be tested in humans, they show great potential for the therapy of rheumatoid arthritis and other inflammatory diseases, the researchers say.

###

The authors acknowledge funding from the National Natural Science Foundation of China, the Guangzhou Municipal Science and Technology Project and the Key Research and Development Project of Lishui.

The paper’s abstract will be available on Feb. 24 at 8 a.m. Eastern time here: http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.0c04438

For more of the latest research news, register for our upcoming meeting, ACS Spring 2021. Journalists and public information officers are encouraged to apply for complimentary press registration by emailing us at [email protected]

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a specialist in scientific information solutions (including SciFinder® and STN®), its CAS division powers global research, discovery and innovation. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact [email protected]

Follow us: Twitter | Facebook

Media Contact
Katie Cottingham
[email protected]

Tags: BiochemistryChemistry/Physics/Materials SciencesMedicine/HealthMusculatureNanotechnology/MicromachinesPain
Share12Tweet8Share2ShareShareShare2

Related Posts

In vitro-generated female germ cells entering meiosis in artificial ovary

Turning X chromosome “off and on again” critical for oocyte development

May 23, 2022
Image 1

Research sheds light on crimean-congo hemorrhagic fever disease process

May 20, 2022

Where do “Hawaiian box jellies” come from?

May 20, 2022

Resolution time of COVID vaccine-related lymphadenopathy

May 20, 2022
Please login to join discussion

POPULAR NEWS

  • Weybourne Atmospheric Observatory

    Breakthrough in estimating fossil fuel CO2 emissions

    46 shares
    Share 18 Tweet 12
  • Hidden benefit: Facemasks may reduce severity of COVID-19 and pressure on health systems, researchers find

    44 shares
    Share 18 Tweet 11
  • Discovery of the one-way superconductor, thought to be impossible

    43 shares
    Share 17 Tweet 11
  • Sweet discovery could drive down inflammation, cancers and viruses

    43 shares
    Share 17 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Zoology/Veterinary ScienceVaccinesUrogenital SystemVirologyVehiclesUrbanizationVirusUniversity of WashingtonVaccineWeaponryWeather/StormsViolence/Criminals

Recent Posts

  • Staying flexible
  • Price noise proves the key to high performing ‘bets against beta’ investment strategies
  • California shellfish farmers adapt to climate change
  • National Comprehensive Cancer Network honors oncology leaders promoting progress in cancer care
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....