• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, February 27, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

The ebb and flow of brain ventricles

Bioengineer by Bioengineer
November 5, 2020
in Chemistry
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Expansion of ventricles in MS patients often recedes

IMAGE

Credit: Millward et al., MDC

It is not only the heart that has chambers – the brain does, too. Its four ventricles are connected to the spinal canal and filled with a clear liquid called cerebrospinal fluid, which removes metabolic waste from the neurons. If the brain becomes inflamed, immune cells also circulate in this fluid. This is the case in diseases like multiple sclerosis (MS), where the immune system attacks the body’s own protective layer around axons (nerve fibers) in the brain and spinal cord. This triggers inflammation, which ultimately leads to the destruction of neurons.

Usually, the brain’s ventricle volume remains fairly constant. However, in 2013, Dr. Sonia Waiczies and her colleagues from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité – Universitätsmedizin Berlin made a discovery in an MS animal model: They observed that the ventricle volume changed over the course of the disease. When they used an antigen to trigger encephalitis (inflammation of the brain) in mice, MRI scans clearly showed that the ventricles expanded. “Everyone thought it was a sign of brain atrophy,” Waiczies recalls.

The swelling goes back down

If the brain’s ventricles become larger, it follows that the brain must become smaller. After all, the surrounding skull bone leaves it with nowhere else to go. Inflammation does indeed cause brain tissue damage, but atrophy – i.e., a massive loss of brain volume –
does not always occur immediately . And if it did, this process would be non-reversible. “So we conducted a series of further animal experiments, and monitored the brain volumes over two months,” says the neuroimmunologist and senior author of the current study. About ten days after the encephalitis was induced, the rodents’ brain ventricles were significantly enlarged. Then, a few days later, they shrunk back to normal size when the symptoms remitted. Just like the patients, they went on to develop temporary relapses – albeit with milder symptoms than at first – and the ventricles would again become enlarged.

Waiczies, who also works as an MR scientist, finds these results quite logical: “If I have an inflamed joint, for example, an edema forms and it swells up. Once the inflammation subsides, the swelling also goes down.” The team is interested in the molecular mechanisms behind these changes. But first, they wanted to know whether their findings had clinical relevance.

Archival data confirms new findings

Enlarged brain ventricles in people with MS is commonly thought to be a sign of brain atrophy. A reduction in ventricle size had never been reported in patients. So what does this observation mean for MS patients? And can the finding even be transferred from mice to humans? The current study saw the researchers test this with the help of extensive MRI data sets of MS patients. From 2003 to 2008, they had participated in a clinical trial at the Charité to test the effects of a new MS drug. “I was involved in the immunological planning and evaluation of this study, and I knew that the generated MRI data was extensive and robust,” says Waiczies.

A diagnosis of multiple sclerosis is made from MR images and by analyzing cerebrospinal fluid obtained by puncturing the spinal cord. Regular scans allow a better prognosis of disease progression. In this study, participants had received a monthly MRI scan. Countless images now had to be viewed and statistically evaluated. Lead author Dr. Jason Millward, neuroimmunologist at the MDC and Charité and statistics enthusiast, set to work on the new study.

“The key factor was the number of measurements taken over time, which provided us with a unique opportunity to see if the patients exhibited similar trends,” explains Millward. That was indeed the case: “The majority of patients with relapsing-remitting MS exhibited fluctuations in ventricle volume – just as we observed with the mice.” Interestingly, Millward also found that the patients with changes in ventricle volume seemed to be in an earlier stage of the disease.

“We are used to seeing ventricular enlargement in other neurodegenerative diseases – such as Alzheimer’s or Parkinson’s disease. But in those diseases, rather than being reversible, the ventricles just keep expanding,” explains Professor Thoralf Niendorf of the MDC, who also works at the Experimental and Clinical Research Center (ECRC), a joint institution of the MDC and Charité. “Regular monitoring of ventricle volume in MS patients could help to distinguish temporary fluctuations from progressive brain atrophy.” This would also make it possible to better tailor therapies to the individual patient.

Professor Friedemann Paul, a clinical neuroimmunologist at Charité and, together with Waiczies and Niendorf, the current study’s senior author, adds: “From a clinical perspective, examining fluctuations in ventricle volumes in routine MRI patient scans could be an interesting approach to monitoring the course of the disease or of immune therapies. But this will require us to study even larger cohorts over a longer period of time. Comparing these results with clinical findings – for example, regarding cognition – is also going to be important.”

The researchers now want to understand how the “ebb and flow” of brain ventricles occurs at the molecular level.

###

Media Contact
Dr. Sonia Waiczies
[email protected]

Related Journal Article

http://dx.doi.org/10.1172/jci.insight.140040

Tags: Biomechanics/BiophysicsMedicine/Healthneurobiology
Share12Tweet8Share2ShareShareShare2

Related Posts

IMAGE

C-Path and Global Partners launch Ataxia Consortium

February 26, 2021
IMAGE

Quantum quirk yields giant magnetic effect, where none should exist

February 26, 2021

Meteorites remember conditions of stellar explosions

February 26, 2021

How photoblueing disturbs microscopy

February 26, 2021

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    Terahertz accelerates beyond 5G towards 6G

    638 shares
    Share 255 Tweet 160
  • People living with HIV face premature heart disease and barriers to care

    82 shares
    Share 33 Tweet 21
  • Global analysis suggests COVID-19 is seasonal

    38 shares
    Share 15 Tweet 10
  • HIV: an innovative therapeutic breakthrough to optimize the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Technology/Engineering/Computer ScienceMedicine/HealthcancerInfectious/Emerging DiseasesEcology/EnvironmentMaterialsCell BiologyClimate ChangeBiologyGeneticsPublic HealthChemistry/Physics/Materials Sciences

Recent Posts

  • Predicts the onset of Alzheimer’s Disease (AD) using deep learning-based Splice-AI
  • When foams collapse (and when they don’t)
  • UTA researcher explores effects of trauma at the cellular, tissue levels of the brain
  • Picture books can boost physical activity for youth with autism
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In