• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Wednesday, January 20, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Science

Texas Tech Health Sciences Center research targets medications for those with depression

Bioengineer by Bioengineer
October 29, 2016
in Science
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: TTUHSC

"The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors," was published in the September issue of the journal Neuropharmacology.

These receptors, which are members of the pentameric ligand-gated ion channel (pLGIC) family abundant within and outside the human brain, are implicated in the causation and development of psychiatric disorders such as anxiety and depression as well as schizophrenia, irritable bowel syndrome, addiction and substance abuse and cognitive dysfunction.

More than 30 years ago, researchers discovered that molecular targets for bupropion were certain reuptaketransporters within the brain neuronal networks. Drugs modulating the function of these transporters were considered good for the treatment of depression. Years later in 1999, researchers found bupropion also inhibited nicotinic receptors and thus could help with smoking cessation.

In this recent study, the research team lead by Michaela Jansen, Pharm.D., Ph.D., at the TTUHSC Department of Cell Physiology and Molecular Biophysics, examined the ability of bupropion and its primary metabolite hydroxybupropion to block the function of serotonin type 3A receptors (5-HT3ARs).

"For a long time, the blockade of dopamine and norepinephrine reuptake by the antidepressant bupropion within the hypofunctioning central nervous system monoamine systems has remained one of the pharmacological underpinnings for its therapeutic efficacy," Akash Pandhare, M.D., Ph.D., first author of the study and researcher at the TTUHSC Department of Cell Physiology and Molecular Biophysics, said. "This study for the first time established the 5-HT3ARs as a hitherto unidentified molecular target of bupropion."

The World Health Organization estimates 350 million people suffer from depression. Many FDA prescription medications cause multiple side effects. Jansen believes these novel findings will bring new hope to those who suffer from depression.

"The research will provide the basis for the development of improved pharmacological interventions for both addiction and depression," Jansen said.

Jansen's team's research demonstrates blockade by bupropion as well as its major metabolite at 5-HT3ARs clinically-relevant concentrations. The research findings of Jansen's team now will be a part of medical and pharmacy textbooks. The research team included Pandhare, Jansen, Aneesh Satya Pappu, Ph.D., Henrik Wilms, M.D., Ph.D., Michael Paul Blanton, Ph.D. The research was supported in part by a seed grant from the South Plains Foundation and a grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health.

"Now when a psychiatrist prescribes this drug, they also will have a better understanding of how it works as an antidepressant," Pandhare said.

###

Media Contact

Suzanna Cisneros
[email protected]
806-743-7605
@ttuhsc

http://www.ttuhsc.edu

Share12Tweet7Share2ShareShareShare1

Related Posts

Five or more hours of smartphone usage per day may increase obesity

July 25, 2019
IMAGE

NASA’s terra satellite finds tropical storm 07W’s strength on the side

July 25, 2019

NASA finds one burst of energy in weakening Depression Dalila

July 25, 2019

Researcher’s innovative flood mapping helps water and emergency management officials

July 25, 2019
Next Post

Ancient strain of cholera likely present in Haiti since colonial era

When fat cells change their color

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    The map of nuclear deformation takes the form of a mountain landscape

    54 shares
    Share 22 Tweet 14
  • People living with HIV face premature heart disease and barriers to care

    61 shares
    Share 24 Tweet 15
  • New drug form may help treat osteoporosis, calcium-related disorders

    40 shares
    Share 16 Tweet 10
  • Blood pressure drug may be key to increasing lifespan, new study shows

    44 shares
    Share 18 Tweet 11

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Chemistry/Physics/Materials SciencesTechnology/Engineering/Computer ScienceClimate ChangeCell BiologyPublic HealthEcology/EnvironmentMaterialscancerMedicine/HealthBiologyGeneticsInfectious/Emerging Diseases

Recent Posts

  • Methamphetamine overdose deaths rise sharply nationwide
  • Breakthrough in understanding ‘tummy bug’ bacteria
  • Stealing the spotlight in the field and kitchen
  • Genome editing to treat human retinal degeneration
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In