Notch Turns Off Hedgehog Through a Three-Enzyme Ubiquitin Module to Build the Stem Cell Niche
In the Drosophila ovary, Notch activation upregulates the E2 enzyme Ubc10, which teams with the E3 ligases Ari-1 and Cul3 ...
Tag: Ubiquitin ligase
Plant Hormone Switch Revealed: How Stressed Seedlings Decide to Pause Growth
New research reveals that a COP1-HY5-ABI5 feedback loop acts as a molecular switch controlling how germinated seedlings pause growth under ...
Virus-driven lymphoma cells rely on a mitochondrial enzyme duo to dodge cell death
New research reveals that the mitochondrial ubiquitin ligase MARCHF5 helps KSHV-transformed lymphoma cells survive by degrading NOXA, the natural antagonist ...
Quality Control Mechanisms at Stalled Ribosomes
In the intricate world of cellular biology, the phenomenon of translation termination is a pivotal event in the protein synthesis ...
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