Tumors Are Not Sterile: How Microbes Living Inside Cancers Reshape Immunity and Immunotherapy
A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...
Tag: tumor-associated macrophages
Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
Molecular Scissors: Cysteine Peptidases Emerge as Master Switches of Antitumor Immunity
A new review in iMetaMed reveals how cysteine peptidases such as cathepsins B, S, L, and X control antigen presentation ...
Immune Cells Feed Breast Cancer Tumors as AI and DNA Testing Reshape Cancer Care
New MSK studies reveal that immune cells secretly feed triple-negative breast cancer, a CXCR2 blocker sensitizes leptomeningeal metastases to radiation, ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
RGS Proteins Emerge as Hidden Architects of the Tumor Microenvironment
A new review in the Journal of Translational Medicine details how RGS proteins, the off switches of GPCR signaling, reshape ...
Blood Levels of Liver Cancer Drug Lenvatinib Predict Who Responds to Treatment
A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...
Breast Cancer Cells Recruit Immune Allies Through TNFAIP3 to Drive Metastasis
A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining ...
Sugar Switch on Immune Cells Could Push Macrophages Back Into Cancer-Fighting Mode
Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...
SPP1 emerges as a master switch shaping the tumor immune landscape
A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...
Gut Microbes May Shape Glioblastoma Immunity, But Evidence Falls Short of Proof
A new review finds growing preclinical evidence that the gut microbiome can influence glioblastoma immunity, while warning that human evidence ...
Tumor Protein CEMIP Hijacks Immune Cells to Fuel Colorectal Cancer Drug Resistance
New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...
MRI Scans Reveal Hidden Cell Neighborhoods That May Signal Breast Cancer Spread
Researchers at Fudan University Shanghai Cancer Center have linked MRI-visible features such as background parenchymal enhancement and peritumoral edema to ...
Lactate and Acetate Exchange Between Tumor-Associated Macrophages and Cancer Cells Fuels Hepatocellular Carcinoma Metastasis
In a groundbreaking study emerging from China, researchers have unveiled a critical metabolic mechanism that exacerbates the metastasis of hepatocellular ...
Scientists Identify Immune Cells Driving Prostate Cancer Treatment Resistance and Discover Method to Overcome Them
In a groundbreaking study that promises to reshape our understanding of prostate cancer progression and immunotherapy resistance, researchers have identified ...
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