Immune Gene Signatures Converge on FLT3 in Prostate Cancer Analysis
A combined bulk and single-cell transcriptomic study identifies FLT3 and AIM2 among immune-associated genes in prostate cancer, while cell-line knockdown ...
Tag: Transcriptomics
Gene Variants Linked to Sweetness-Acid Balance in Watermelon Fruit
A combined transcriptomic and genomic study of two contrasting watermelon accessions identifies candidate genes, including a pectin lyase-like protein and ...
Cold-exposed frog livers rewire metabolism toward glucose production and fat storage
A five-day cold exposure at 5 °C triggers hyperglycemia and a coordinated transcriptional shift in the Xenopus laevis liver toward ...
Aging Immune Signal Identified as a Conserved Brake on Nerve Regeneration
Peripheral nerves lose much of their ability to repair themselves as bodies age, and a new comparative genomics study points ...
Astrocyte State Linked to Brain Scaffolding Emerges as Biomarker Clue in Depression
An integrative transcriptomic study has identified an extracellular matrix and perineuronal net-high astrocyte state in major depressive disorder, along with ...
Plaque Transcriptomics Point to BCAP31 as a Stress Buffer in Carotid Atherosclerosis
An integrated analysis of human carotid plaque transcriptomes and macrophage experiments suggests that elevated BCAP31 in atherosclerotic lesions may reflect ...
Rare tau gene variant reshapes brain cell transcriptomes in Alzheimer’s and PSP
Single-nucleus RNA sequencing of postmortem brains reveals that carriers of the rare MAPT A152T variant show distinct cell type-specific gene-expression ...
Mouse study finds intracellular ZP2 supports early embryo development
A mouse embryo study found that partial depletion of intracellular ZP2 delayed blastocyst formation, reduced trophectoderm and primitive endoderm, and ...
Public-data reanalysis identifies cell-cycle signal in sinonasal cancer
A public-data reanalysis identified broad tumor-normal gene-expression changes in sinonasal squamous cell carcinoma and nominated four preliminary candidate biomarkers supported ...
RNase 2 shapes macrophage antiviral responses through targeted tRNA cleavage
A study in human macrophages found that RNase 2 supports antiviral gene expression and selectively generates transfer-RNA fragments during responses ...
Hormonal and transcriptomic signatures of scion-associated early growth suppression in Camellia oleifera
A five-stage graft-healing study associates weak first-year growth in ‘Changlin 53’ camellia scions with delayed tissue repair, altered hormone timing ...
Machine Learning Identifies Two Gene Markers of Allergic Rhinitis
A cross-algorithm analysis of public nasal-tissue data identified TNFSF14 and CD83 as a two-gene panel that distinguished allergic-rhinitis samples from ...
Glycolysis Diverges from Its Transcripts in Human Hypertrophic Cardiomyopathy
A multi-omics analysis of human hypertrophic cardiomyopathy found suppressed glycolytic transcription but divergent enzyme-protein changes, while oxidative pathways declined more ...
Genetic and cell studies point to miR-539-3p–SOX9 pattern in keloids
A multi-method study prioritized miR-539-3p and SOX9 as linked candidates in keloid tissue and fibroblasts, while leaving their regulatory relationship ...
Candidate grapevine rust effectors suppress AvrB-triggered plant cell death in laboratory assay
A transcriptomic, microscopy and functional study of Neophysopella tropicalis identified 303 candidate effectors, including six that suppressed AvrB-triggered plant cell ...
Synthetic organelle records transient gene activity in human cells
A mitochondria-anchored synthetic organelle captured up to 90% of expressed gene transcripts in human cells and preserved transient interferon-response histories ...
TIMP1 linked to anoikis resistance and metastasis in esophageal cancer
Single-cell and bulk transcriptomic analyses linked TIMP1 to anoikis resistance in esophageal squamous cell carcinoma, while cell and mouse experiments ...
Gut microbes track pigeon muscle quality differences in multi-omics study
A multi-omics comparison links strain-specific gut microbes and intestinal features to candidate differences in pigeon breast-muscle metabolism and meat quality, ...
Blood RNA markers illuminate protein-modification networks in heart attacks
A transcriptomic study identified GABARAPL1, PELI1 and NLRP3 as elevated blood RNA markers associated with acute myocardial infarction, while highlighting ...
Quercetin reduces acute inflammatory and matrix-remodeling markers in mouse intracerebral hemorrhage
An experimental study found that quercetin reduced selected inflammatory and extracellular matrix-remodeling markers 24 hours after mouse intracerebral hemorrhage, while ...
