Gastric Cancer Metastasis Patterns Reveal Distinct Molecular Targets
A new review in Annals of Gastroenterological Surgery proposes treating gastric cancer metastasis as distinct patterns, identifying route-specific biomarkers and ...
Tag: therapeutic targets
Review Highlights Multi-Target Therapeutic Potential of Kava Compound Flavokawain A
A scientific review evaluates the molecular mechanisms, signaling pathways, and preclinical therapeutic potential of the kava chalcone Flavokawain A across ...
Mendelian Randomization Study Identifies Plasma Protein Targets for Macular Degeneration
A multi-omics Mendelian randomization study identified 22 plasma proteins associated with age-related macular degeneration, highlighting four high-confidence therapeutic candidates.
MicroRNAs May Program Premature Lung Disease Before Birth
An educational review argues that bronchopulmonary dysplasia arises from microRNA dysregulation spanning placental development through neonatal lung injury.
Research report: Unraveling the iron grip: ferroptosis and its role in cardiovascular diseases
A new open-access review in Cell Biology and Toxicology examines how ferroptosis, an iron-dependent form of cell death, may contribute ...
ZFX Drives T-cell Leukemia Growth Through m5C Methylation of PD1 mRNA
A new study shows that ZFX promotes T-cell acute lymphoblastic leukemia by activating NSUN2-mediated m5C methylation, which stabilizes PD1 mRNA.
How the STIM1 protein and store-operated calcium entry shape health and disease
A new review synthesizes how the calcium sensor STIM1 and store-operated calcium entry regulate physiology across tissues and contribute to ...
Geneticists certify 108 high-confidence Alzheimer’s risk signals
A systematic adjudication framework applied to 29 genome-wide studies produced a catalog of 108 high-confidence genetic signals for Alzheimer's disease ...
Cell benchmark study finds specialized AI matches frontier models in aging biology
A Cell study found that aging-specialized language models matched or surpassed 16 general-purpose frontier systems on a benchmark spanning clinical ...
Cysteine Dependence Reveals Metabolic Weakness in Small Cell Lung Cancer
Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...
LPA₃ signaling and biological functions: from physiological regulation to disease-targeted therapy
A 2026 review summarizes LPA₃ signaling across tissues and diseases, identifies possible therapeutic applications, and frames selective antagonists, biased ligands ...
Climbing the causal ladder: a new framework sorts real cancer drug targets from statistical noise
A new evidence-accounting framework called the Causal Integration Ladder separates statistical association from causal, therapeutically tractable mechanism in cervical cancer, ...
Ovarian Cancer’s Hidden Weakness: An Arginine Gateway on the Cell Surface
A detailed map of proteins on the surface of high-grade serous ovarian cancer cells has revealed that these tumors depend ...
The Golgi Apparatus Emerges as a Hidden Driver of Alzheimer’s Disease
A new review argues that the long-overlooked Golgi apparatus, supported by human genetic, proteomic, and lipidomic evidence, may be a ...
Tiny Vesicles, Big Problem: How Exosomes Drive Cancer Immunotherapy Resistance
A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...
Cellular Contact Points Called MAMs Emerge as Central Players in Heart Attack Damage
A new review in the Journal of Translational Medicine argues that mitochondria-associated endoplasmic reticulum membranes integrate lipid metabolism and ferroptosis ...
Ferroptosis in Cancer: Metabolism and Therapeutic Opportunities
Ferroptosis, a form of regulated cell death distinct from apoptosis and necrosis, has emerged at the forefront of cancer research, ...
GPR182 Impedes Angiogenesis by Modulating CXCL12-CXCR4 Signaling
Recent research has unveiled a significant mechanism in the realm of angiogenesis, the process by which new blood vessels form ...
Piezo1 Activation Amplifies Limb Ischemia-Reperfusion Injury
Recent groundbreaking research published in the journal Experimental & Molecular Medicine reveals critical insights into the role of Piezo1 activation ...
ANGPTL3-Integrin α5 Link Fuels Diabetic Retinopathy Leakage
In a groundbreaking study, researchers have unveiled the crucial role of the ANGPTL3-integrin α5 axis in driving retinal vascular leakage, ...
