Neutrophils Shape Brain Injury and Repair in Neonatal Encephalopathy
A scientific review details how neutrophils drive early inflammation and late neural repair following neonatal hypoxic-ischemic brain injury.
Tag: therapeutic hypothermia
Brain Energy Failure Framework Unifies Cellular Damage in Perinatal Asphyxia
A narrative review links mitochondrial breakdown, neuroinflammation, and endocrine stress responses within an integrative model of perinatal hypoxic-ischemic brain injury.
Half of infants evaluated for but not cooled show developmental delays at age two
A prospective cohort study found that 50% of infants evaluated for but not treated with therapeutic hypothermia showed sub-normative performance ...
Neonatal researcher Kata Kovacs links early phosphate levels to mortality risk in newborn encephalopathy
A Pediatric Research biocommentary profiles neonatal researcher Kata Kovacs, whose latest study links elevated serum phosphate at six hours of ...
Tiny RNA Molecule Shields Newborn Brains from Oxygen-Starved Cell Death
New rat and cell experiments show that the microRNA miR-7a-5p protects the neonatal brain from hypoxic-ischemic injury by suppressing PARP1-driven ...
Blood Pressure Cuff Technique Shows Early Safety Promise for Severe Childhood Brain Condition
A commentary in Pediatric Research finds that remote ischemic postconditioning is safe and feasible in children with AESD, clearing the ...
Gut Microbe Metabolites May Rescue Newborn Brains by Breaking a Deadly Cellular Feedback Loop
A new review argues that gut-derived short-chain fatty acids, especially butyrate, could protect newborn brains from hypoxic-ischemic injury by breaking ...
From Deep Brain Stimulation Dreams to Watching Newborn Brains: The Unlikely Path of a Neonatal Physiologist
Harvard pediatric researcher John Sunwoo transformed an early ambition to reverse-engineer the brain into a career using diffuse correlation spectroscopy ...
Cooling the Beating Heart: Hypothermia Plus Ventricular Unloading Shields Vulnerable Heart Muscle After Attack
A porcine study shows that combining moderate therapeutic hypothermia with mechanical left ventricular unloading preserves function, mitochondria, and calcium handling ...
Orexin-A Trajectories in Newborn Brain Injury Reveal Cooling’s Hidden Signature
A prospective study of 41 newborns with hypoxic-ischemic encephalopathy found that serum orexin-A followed divergent early trajectories depending on therapeutic ...
Predicting Mortality in Infants with Neonatal Encephalopathy
In an era where neonatal care continuously advances, a groundbreaking study has emerged from the research teams led by Mitchell, ...
Cooling Debate in Late Preterm Neonatal Encephalopathy
In the realm of neonatal care, one of the most challenging dilemmas has emerged concerning the management of late preterm ...
Day-2 Heart Imaging and Biomarkers in HIE Neonates
In the rapidly evolving field of neonatal care, one of the most formidable challenges remains the early detection and management ...
Suspected Hypoxic-Ischaemic Neonatal Encephalopathy Explored
In recent years, neonatal encephalopathy resulting from suspected hypoxic–ischaemic encephalopathy (HIE) has emerged as a critical subject of investigation in ...
Regional rollout of therapeutic hypothermia for neonatal encephalopathy
In a groundbreaking advancement for neonatal care, researchers have unveiled a pioneering approach to the implementation of active therapeutic hypothermia ...
