Tag: targeted protein degradation

A literature review in Medicine Plus indicates that the cGAS-STING pathway operates as a context-dependent signaling network capable of driving ...

A molecular dynamics investigation demonstrates that a computationally designed DNA aptamer can function as a molecular glue to stabilize the ...

Researchers have identified that cytosolic EZH2 functionally inactivates Rb to drive CDK4/6 inhibitor resistance in ER-positive, HER2-negative metastatic breast cancer, ...

Researchers have identified an optimised sesquiterpene lactone derivative that selectively degrades CDK4 via SKP2 to induce cell death in non-small ...

Researchers have engineered a cell-penetrating TRIM21-based protein degrader that targets all three PIM kinase isoforms to induce apoptosis in breast ...

A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...

Chemically modified BRD4 degraders MZ-1-ME and SIM-1-ME showed enhanced protein degradation and growth inhibition in a KSHV-infected endothelial cell model ...

A new review outlines translational frameworks for using targeted protein degradation to eliminate the proteins that drive acquired resistance in ...

A Cell Division review maps how ubiquitination links diabetic stress to protein turnover, mitochondrial function, inflammation, and cell death in ...

A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...

A review identifies post-endocytic routing as the decisive step in targeted lysosomal degradation and proposes a five-tier framework for verifying ...

A new computational study suggests that next-generation CRBN E3 ligase modulators, particularly CC-885, may hold the key to overcoming mutation-driven ...

Researchers have developed fluorescence polarization and thermal shift screening methods to identify small-molecule bait ligands for the bacterial ClpC N-terminal ...

New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...

Researchers report that the approved HIV protease inhibitor ritonavir binds the HCMV immediate-early protein IE1 and promotes its ubiquitin-proteasome-mediated degradation, ...

High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...

Chemists have developed ruthenium-based photocaged PROTACs, called RuPHOTACs, that can be switched on with low-energy red light to selectively degrade ...

A comprehensive epigenomic map of medulloblastoma reveals that the chromatin regulator KDM2B sustains the highest-risk tumor subgroups by locking neuronal ...

A Baylor College of Medicine-led team combined high-throughput proteomics and AI-based structural prediction to discover and optimize a new class ...

In a breakthrough that promises to redefine the landscape of targeted protein degradation, researchers have unveiled a novel class of ...