Inside the Cryo-FIB Workflow That Makes 3D Imaging of Frozen Cells Possible
A new review explains how cryo-FIB-SEM sits at the center of the cryo-electron tomography workflow, from vitrification and target-guided milling ...
Tag: structural biology
AI Reads Protein Alignment Images Well by Name, Fumbles Residue Boundaries
Vision–language models read region names from multiple sequence alignment images accurately but fail badly at defining residue boundaries, where a ...
New web tool brings molecular docking to any researcher’s browser
University of Tsukuba researchers have launched "Anyone Can Dock," a browser-based platform that automates molecular docking workflows and adds AI-assisted ...
Vitrobot-based protocol makes graphene oxide cryo-EM grids reproducible and accessible
A new Vitrobot-based protocol produces graphene oxide cryo-EM grids with 55 percent average coverage and supports apoferritin and β-galactosidase reconstructions ...
Cryo-EM reveals how Andes hantavirus grips its human cell receptor
A new Nature study shows that the Andes virus spike captures the PCDH1 receptor through a deep central pocket that ...
$16.4 Million NIH Award Launches Multi-Institution Center for Hepatitis C Vaccine Design
The NIH has awarded $16.4 million over five years to a new multi-institution U19 center led by Scripps Research to ...
PyMOL plugin brings protein circuit topology into the molecular viewer
An open-source PyMOL plugin integrates protein circuit topology analysis, visualization, trajectory processing and compaction scoring into an interactive molecular-viewing workflow.
Inside the Molecular Cities of Bacteria: New Imaging Reveals How Cellular Factories Work Together
Two new cryo-electron tomography studies from EMBL Heidelberg reveal how protein production, transport, and folding are interconnected in bacterial cells, ...
How Seven Tiny Mutations Break a Metabolic Enzyme and Cause a Rare Brain and Heart Syndrome
New crystal structures and biochemical analyses reveal that seven disease-causing SHMT2 mutations sabotage the same mitochondrial enzyme through strikingly different ...
Molecular Measuring Tape: How Plants Measure Fungal Signals to Tell Friend from Foe
Researchers at Aarhus University have discovered that a plant receptor called CHIP13 acts as a molecular measuring tape, using a ...
RFdiffusion3 designs proteins and nucleic acids atom by atom with striking precision
The new generative AI system RFdiffusion3 designs proteins and nucleic acids atom by atom, producing functional enzymes and RNA molecules ...
New RNA structure toolkit picks winning 3D models from eleven predictors
A new open-source framework called ROMET-RNA benchmarks eleven RNA 3D structure predictors and three alignment pipelines, using a consensus scoring ...
Hybrid docking-assembly algorithm cracks the structures of giant protein complexes
A new hybrid framework called HDOCK-Multimer combines protein-protein docking with combinatorial assembly to predict the structures of large protein complexes ...
Opioid drugs reach deep into their G proteins, single-molecule study reveals
Single-molecule FRET imaging shows that opioid ligands allosterically tune the conformational dynamics of bound G proteins over 70 angstroms away, ...
New Dashboard Brings Protein Structure Into the Hunt for Disease-Causing Gene Variants
Researchers have developed ProtSAVI, an R-based dashboard that combines protein structure analysis with ACMG/AMP criteria to reclassify variants of uncertain ...
Hepatitis C Vaccine Design Gains Ground as Structures Reveal How Naive Antibodies See Viral Envelope
New structural and biochemical analyses of the hepatitis C virus E2 glycoprotein show that germline-reverted broadly neutralizing antibodies recognize the ...
Cryo-EM Exposes Hidden Architecture of a Bacterial Antiviral Weapon Found in Pathogens
Cryo-electron microscopy has revealed the first structure of a TenpIN type III toxin-antitoxin complex common to several pathogenic bacteria, showing ...
Ancient Microbe Reveals a Surprising New Route to Natural Fertilizer
Saint Louis University researchers have revealed an unexpected nitrogenase supercomplex in an ancient methanogen, a structural discovery that could transform ...
Cryo-EM Captures 76 RNA Shapes at Once, Rewriting How Ribozymes Work
Researchers have resolved 76 coexisting conformers of the RNase P ribozyme at near-atomic resolution, revealing that catalysis arises from dynamic ...
Molecular Movie Captures Penicillin Being Built Atom by Atom
Using X-ray free-electron lasers, Oxford-led researchers have captured a frame-by-frame molecular movie revealing the previously unseen intermediates through which the ...
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