Methylated translation factor speeds decoding of rare codons to drive cancer growth
A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS production and driving resistance ...
Tag: sotorasib
Next-generation KRAS inhibitor divarasib extends survival in advanced lung cancer
A Phase 3 trial found the next-generation KRAS G12C inhibitor divarasib extended median overall survival to 17.7 months versus 12 ...
Newly found enzyme pathway helps cancer cells churn out KRAS growth proteins
New research from MD Anderson shows the METTL13 enzyme helps cancer cells selectively produce growth-driving proteins such as KRAS, and ...
Molecular dynamics show docking proximity alone cannot guarantee KRAS G12C covalent inhibition
Molecular dynamics simulations reveal that near-reactive docking geometries in KRAS G12C ligands rapidly collapse unless an explicit covalent bond stabilizes ...
Cediranib plus KRASG12C inhibitors triggers replication stress and antitumor immunity
A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...
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