Tag: single-cell RNA sequencing

Every cell in the human body carries a hidden archive of its past. Now researchers at Erasmus University Medical Center ...

A multi-cohort transcriptomic, genetic, and experimental study identifies the RHBDF2–ADAM17–TNFα axis as a molecular bridge linking ulcerative colitis to blood–brain ...

A donor-aware single-cell analysis links membranous nephropathy to an LXR-linked cholesterol-handling state in kidney tubule cells and reveals a matching ...

Researchers in Tokyo engineered a tracking system for Foxp3-deficient regulatory T cells and found that combined loss of Foxp3 and ...

Long-term live imaging of mouse skin reveals that epidermal stem cells feed a transit-amplifying hierarchy whose turnover speed and coordination ...

A single-cell RNA sequencing study of murine gammaherpesvirus 68 reveals that macrophage infection can follow three distinct outcomes, a restricted ...

Researchers generated mouse embryo models entirely from chemically induced totipotent-like stem cells that self-organized through gastrulation, blood formation and beating ...

A new review argues that inflammasome-derived molecular biomarkers could predict wound outcomes, distinguish healing from chronic inflammation, and guide precision ...

Single-cell transcriptomics and proteomics have revealed that human plasma cells selectively express a non-caveolar Caveolin-1β isoform induced by XBP1, positioning ...

A multi-omics study identifies ISG15-positive CD8 T cells and a CCL2-CCR2-mediated inflammatory loop as drivers of immune checkpoint inhibitor-induced myocarditis, ...

A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...

By merging bulk and single-cell RNA sequencing with machine learning and lab experiments, researchers have identified smooth muscle cells as ...

A multi-omics study identifies the mitochondrial pyruvate carrier gene MPC2 as a causal link between hypoxia, mitochondrial energy failure, and ...

An integrative study links the tire-derived pollutants 6PPD and 6PPD-quinone to molecular signatures and increased susceptibility of atrial fibrillation through ...

A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...

A new study shows that embryonic lineage identity, encoded through mitochondrial dynamics and epigenetic silencing of CDK8, determines why blocking ...

University of Oxford researchers have discovered that a specialised population of human microglia protects dopamine neurons in Parkinson's disease by ...

A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...

A cross-species study shows that the gut bacterium Clostridium butyricum and its metabolite butyrate alleviate obesity by disrupting an LPS-EGR1 ...

New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...