Tag: single-cell RNA sequencing

Single-cell and bulk transcriptomic analyses linked TIMP1 to anoikis resistance in esophageal squamous cell carcinoma, while cell and mouse experiments ...

A local genetic screen linked MST1, DLK1, ITIH1 and SAA1 to intervertebral disc-disorder outcomes, while single-cell tissue analysis and a ...

A network-pharmacology and cell-based study identified 95 candidate targets for Pei Yuan Yi Fei decoction in non-small cell lung cancer, ...

A retrospective cohort of 21 adults with acetylcholine receptor antibody-positive generalized myasthenia gravis found improved daily functioning after efgartigimod, while ...

A BMC Cancer abstract reports that public-dataset modeling identified a four-gene prognostic model for prostate adenocarcinoma biochemical recurrence, with supporting ...

StrokeTime integrates 414,359 single-cell transcriptomes from mouse ischemic-stroke studies to trace immune, vascular, glial and neuronal changes from hyperacute injury ...

A mouse organoid system shows that defined signals can separately initiate acinar-to-ductal conversion, sustain metaplastic expansion and promote partial redifferentiation ...

A Roche-led benchmark found that the 10X Genomics GEM-X Flex assay with chop-fix processing improves single-cell RNA profiling of frozen ...

A pan-cancer single-cell framework identifies 667 cell-specific long noncoding RNAs and thousands of functional pairs linked to tumor heterogeneity and ...

A systematic reusability study of the CORNETO framework reveals that multi-sample biological network inference operates in distinct robustness regimes governed ...

A cautious reanalysis of single-cell, TCGA, MRI, and cell-line data links muted type-I interferon signaling and altered cell-state programs to ...

The first single-cell RNA sequencing study of an LGMD R12 patient reveals stalled muscle regeneration, metabolic collapse, and activated immune ...

A cross-species single-cell and spatial transcriptomics study reveals a conserved Notch/AP-1 to fibronectin and thrombospondin signaling axis operating in a ...

A new computational framework links the metabolic enzyme NNMT to coordinated platelet, neutrophil, and immune exhaustion programs in circulating tumor ...

A new study integrating bulk and single-cell RNA sequencing identifies two mitochondrial quality control-related genes with distinct immune and metabolic ...

A new review maps how patient-derived induced pluripotent stem cells and three-dimensional vascular and neurovascular organoids are transforming Moyamoya disease ...

Researchers have discovered inducible germinal center-like structures in the gut of common carp, showing that sophisticated mucosal antibody responses evolved ...

A multiomics study identifies the deubiquitinase OTUD7B as a central driver of epithelial remodelling, mitochondrial reprogramming, and immune suppression in ...

A single-cell and epigenetic study links loss of the retinoid-binding protein CRABP1 to an invasive malignant epithelial cell state in ...

A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...