Tag: single-cell RNA sequencing

New research in Advanced Science reveals that the secreted protein LRG1 drives pathological angiogenesis in bladder cancer by binding ANXA2 ...

Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...

A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...

Researchers converted Duchenne patient stem-cell teratomas into humanized models in which both gene-corrected cell transplants and lipid nanoparticle base editing ...

Researchers have developed CardamomOT, an optimal transport-based framework that jointly infers gene regulatory networks, reconstructs unobserved protein trajectories, and enables ...

New research in PLOS Genetics shows that the metabolic enzyme Arginine Kinase 1 is essential for Drosophila flight muscle development, ...

Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core ...

New research shows that diabetes elevates the histone mark H3K4me1 in pancreatic acinar cells, driving stress granule formation under high ...

A pan-cancer single-cell atlas of nearly 900,000 cells shows that bone metastases from ten cancer types share convergent malignant programs ...

Researchers have identified a stress-responsive subset of MAIT cells that promotes an immunosuppressive peritumoral environment and microvascular invasion in hepatocellular ...

Scientists have engineered human stem cell-derived spheroids containing myelinating oligodendrocytes and reactive microglia that model demyelination and successful remyelination, offering ...

A large human and mouse study shows that salivary proline-rich proteins circulate in serum and track chronic kidney disease with ...

St. Jude scientists and collaborators built a comprehensive single-cell dataset and patient-derived models to identify a malignant mesenchymal cell population ...

A Mass General Brigham study of malignant ascites has identified rare RORC-expressing dendritic cells that may promote immune tolerance in ...

Researchers have built the first cross-tissue single-cell atlas of T cell and B cell receptor repertoires in healthy piglets, revealing ...

A single-cell atlas of the developing Drosophila visual system traces how glial cells diversify from larvae to adulthood and reveals ...

A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...

A new study reveals how SPP1-positive macrophages secrete WNT5A to activate matrix-remodeling fibroblasts in lung adenocarcinoma, building a stiff tumor ...

A new method called CCI-seq captures large-scale cell–cell interaction networks in tissues while preserving full single-cell transcriptomes, revealing interaction-driven gene ...

By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings ...