Splicing Factor LUC7L2 Emerges as a Driver of Kidney Damage from Chemotherapy
New research reveals that the RNA splicing factor LUC7L2 drives ferroptotic kidney damage from cisplatin by corrupting the splicing of ...
Tag: single-cell RNA sequencing
Scientists Uncover a 45-Gene Signature That Predicts Prostate Cancer Spread
Researchers have developed and validated a 45-gene transcriptomic signature, Met-Score, that quantifies metastatic competence in primary prostate tumors and predicts ...
Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...
Endothelial Angptl2 Emerges as Central Driver of Influenza-Linked Lung Fibrosis
New research identifies endothelial Angptl2 as a key molecular driver linking influenza-induced vascular injury to pulmonary fibrosis through EndMT and ...
Computational Framework Ranks Safer RNA-LNP Formulations Before the Lab
Researchers at the University of Catania have built a modular computational framework that ranks RNA-lipid nanoparticle formulations for safety and ...
Hidden Genome: Tiny Proteins Mapped Across the Parasite Behind Trichomoniasis
Researchers have built the first comprehensive atlas of 918 microprotein candidates in Trichomonas vaginalis, confirming translation of 103 of them ...
Single-Cell Sequencing Reveals Cerebral Cavernous Malformations Insights
In a groundbreaking study published in the journal “Angiogenesis,” researchers led by W. Zheng, L. Chen, and J. Ma have ...
Framework Reveals Tumor Metabolic Subtypes Through Single-Cell Data
In the realm of cancer research, the intricate interplay of cellular microenvironments and metabolic processes has long been a focus ...
Single-Cell Insights Into Weight Loss in Fat Tissue
In a groundbreaking study poised to redefine our understanding of adipose tissue plasticity, researchers have revealed the profound cellular and ...
Targeting Mitochondrial Gene HSPE1 in Osteosarcoma Treatment
In an enlightening new study, researchers led by Pan, S., Hu, W., and Xie, P., have unveiled critical insights into ...
Mammalian Striatal Interneurons: Conserved or Changed?
A groundbreaking study recently published in Nature uncovers remarkable conservation and specific adaptations within the interneuronal architecture of the mammalian ...
Overcoming Batch Effects in Single-Cell RNA-seq Datasets
In a groundbreaking study published in BMC Genomics, researchers Hrovatin, Moinfar, Zappia, and their colleagues delve into the complexities of ...
Cross-Study Map Reveals Heart Failure Cell Coordination
In a groundbreaking new study published in Nature Communications, scientists have unveiled a comprehensive cross-study transcriptional patient map of heart ...
New Algorithm Reveals Genetic Links Between Alzheimer’s Disease and Specific Neurons
In a groundbreaking advance poised to transform the field of neurodegenerative disease research, scientists at Rice University, in collaboration with ...
HMGN1 Drives Heart Defects in Trisomy 21
In a groundbreaking study published in Nature, researchers have unveiled a sophisticated functional genomics strategy that unravels the molecular underpinnings ...
Transferability of Self-Supervised Learning in Transcriptomics
Self-supervised learning (SSL) has gained recognition as a transformative approach for effectively extracting meaningful representations from extensive unlabelled datasets in ...
SMOC1 Identified as Key Gene in β-Cell Dedifferentiation
In a groundbreaking study published in Nature Communications, a multinational team of researchers has unveiled new insights into the cellular ...
cDC3s Impair Anti-TNF-α Therapy in Ulcerative Colitis
In a groundbreaking study published in the Journal of Translational Medicine, researchers have unveiled significant insights into the role of ...
Neuron-Reactive KIR+CD8+ T Cells Drive Autoimmune Encephalitis
In a groundbreaking study published in Nature Communications, researchers have unveiled a novel population of immune cells that could redefine ...
See-Through Worms Illuminate Evolutionary Mysteries
In a groundbreaking exploration of evolutionary biology and developmental genetics, scientists have unveiled strikingly conserved gene expression patterns between two ...
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