Review Maps Plant Protein Aggregation Mechanisms and Control Strategies
A 2026 review in Agricultural Products Processing and Storage analyzes the aggregation mechanisms of plant-derived proteins and evaluates physical, chemical, ...
Tag: protein aggregation
Dictyostelium Cellular Stress Alters Solubility of Predicted Prion-Like Proteins
Researchers found that heat and nutrient stress trigger distinct insolubility shifts enriched for predicted prion-like proteins in Dictyostelium discoideum.
Phosphorylation of 14-3-3γ Impairs Its Ability to Limit Alpha-Synuclein Aggregation
A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...
Trehalose Crystallization Undermines Protein Stability in Lyophilized Drug Formulations
A new study shows that trehalose crystallization during freeze-drying, which requires prolonged annealing and high sugar content, creates inhomogeneity that ...
Approved Drugs Dissolve Mutant Polymerase Aggregates and Restore Motor Function in Mice
Two already approved drugs, diltiazem and sulbactam, dissolved mutant POLGA aggregates and restored mitochondrial DNA replication and motor function in ...
Cold triggers a muscle-to-tissue metabolic network in worms
A nematode study shows how cold-induced BH2 production in muscle coordinates longevity and protein homeostasis across distant tissues.
Experimental ALS study identifies interferon-beta immunoproteasome pathway for TDP-43 clearance
An experimental study in ALS models found that an interferon-beta signal can increase motor-neuron immunoproteasome activity and clear aggregation-prone TDP-43 ...
Microplastics Are Not Chemically Inert: Water Turns Their Surfaces Into Radical Factories
A Nature study shows that commodity microplastics spontaneously generate hydroxyl radicals in water through interfacial electrostatics and partial solvation, challenging ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
Stress-Tagged Ubiquitin Emerges as a Molecular Beacon for Toxic Tau in Alzheimer’s Disease
Mayo Clinic researchers report that ubiquitin phosphorylated at serine 65 is covalently attached to a soluble, oligomeric tau population in ...
Water’s Hidden Shape Reveals the Trigger Point That Spreads Dementia Proteins
Northwestern University researchers have identified a single water-defined hotspot on tau proteins that drives the misfolding cascade behind Alzheimer's and ...
AI Meets Living Cells in $28.6 Million Bid to Predict Protein Misfolding Before Disease Strikes
A Stowers Institute scientist will help lead a $28.6 million ARPA-H effort to generate billions of protein aggregation measurements and ...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Synphilin-1 Regulates Alpha-Synuclein Dynamics
In a groundbreaking study published in npj Parkinson’s Disease, researchers have unveiled the intricate role of synphilin-1 in modulating the ...
Glycation Boosts Alpha-Synuclein Aggregation, Neuroinflammation
In a groundbreaking study published in npj Parkinson’s Disease, researchers have shed new light on the molecular mechanisms underpinning Parkinson’s ...
POPULAR NEWS
-
High Trop-2 Linked to Better Survival in Early TNBC
-
Nanomaterial Scaffolds Transform Enzymatic Testing for Biodegradable Liquid Polymers
-
Systematic Review Details Architecture Shifts and Limits of Vision Transformers
-
Nitric Oxide Governs Immune Suppression and Therapeutic Responses in Cervical Cancer