Tag: preclinical study

A collagen-targeted protein MRI contrast agent developed at Georgia State University detected invasive lung tumors and multi-organ metastases as small ...

A preclinical mouse study found that a Matrigel scaffold alone improved histological repair of excisional wounds, with human placenta-derived mesenchymal ...

University of Michigan researchers report that the molecular glue RPT04402 stabilizes the trimeric tumor suppressor PP2A, shrinking KRAS-mutant lung tumors ...

Researchers designed a phenylthioether chalcone compound, B15, that directly binds p38 MAPK and reduced inflammation, oxidative stress and lung tissue ...

A wirelessly powered implantable device that electrocatalytically converts blood glucose into excretable gluconate restored normal glucose levels within an hour ...

A preclinical mouse study found that intraperitoneally delivered macrophages engineered to secrete IL-10 reduced disease activity, preserved colon length, and ...

A rat study shows shear wave elastography detects falling nerve stiffness weeks before conduction tests or histology reveal recovery, offering ...

In a mouse study, a recombinant Echinococcus granulosus protein shifted macrophages toward a repair-associated state by dampening the cGAS–STING pathway ...

Oral pretreatment with the approved A2A receptor antagonist istradefylline significantly delayed and reduced hyperbaric oxygen-induced seizures in male mice, a ...

An engineered fusion of staphylokinase and an endolysin dismantles the fibrin-encapsulated communities of Staphylococcus aureus and outperforms vancomycin in a ...

A combined genetic, cellular, and mouse study finds that semaglutide strengthens gemcitabine's antitumor effect by suppressing RRM1 while weakening methotrexate ...

A new rat study shows that the antidepressant agomelatine suppresses nicotine-induced locomotor sensitization, pointing to a possible repurposing strategy for ...

A dual-photosensitizer light treatment combined with optical clearing eradicated thick pigmented melanoma in mice by triggering a potent, long-lasting anti-tumor ...

A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...

A University of Cincinnati and UC Davis team showed that an AAV gene therapy targeting cerebrospinal fluid-producing cells reduced hydrocephalus-related ...

Researchers have developed an optimized tumor-infiltrating lymphocyte manufacturing protocol that shows preclinical efficacy against NF1- and schwannomatosis-related nerve sheath tumors, ...

A Duke University preclinical study finds that the experimental ATM inhibitor AZD1390 reduced stroke-related brain injury in mice only when ...

Researchers report that adding interleukin-18 to cultures of scarce human Vδ1 T cells boosts their expansion, survival and antitumor performance ...

Scientists have engineered a bispecific antibody that simultaneously blocks TL1A and IL-12/23p40, suppressing pathogenic Th1/Th17 immune responses and significantly ameliorating ...

Oregon State University researchers have shown in mice that cobalt-doped iron oxide nanoparticles can both reveal a misplaced placenta on ...