Tag: Pharmacokinetics

A systematic review and dose-response meta-analysis reveals a nonlinear relationship between serum adalimumab concentrations and clinical response in rheumatoid arthritis, ...

A pilot study in Korea demonstrates that centralized therapeutic drug monitoring of asparaginase is feasible across multiple formulations in pediatric ...

A bibliometric analysis of more than 27,000 publications tracks the growth of cancer siRNA therapies, shifting delivery technologies, and persistent ...

A virtual-patient modelling framework identifies a robust 33-to-67-hour imaging window centered at 50 hours that minimizes both population errors and ...

Researchers demonstrated that the natural pentacyclic triterpene uvaol inhibits blood vessel formation by targeting key kinase enzymes in computational, enzymatic, ...

A randomized trial in lung transplant recipients found that switching from twice-daily to once-daily extended-release tacrolimus does not reduce objective ...

A review in Molecular Cancer examines how antibody-drug conjugates treat solid tumors while addressing clinical resistance, toxicity profiles, and narrow ...

A systematic review examines the cellular mechanisms, pharmacokinetic limitations, and available clinical evidence for the olive oil compound hydroxytyrosol across ...

A narrative review indicates that blood-brain barrier disruption in Alzheimer's disease increases cerebral antipsychotic penetration, triggering parkinsonian side effects and ...

A clinical case series reveals that targeted oral sirolimus therapy induced substantial tumor shrinkage in three neonates with complex head ...

A replicated crossover trial in healthy Chinese volunteers demonstrates that generic vardenafil hydrochloride tablets match branded Levitra in absorption rate ...

A systematic review of 33 clinical studies revealed that food intake primarily alters the rate rather than extent of ADHD ...

A randomized crossover trial in healthy Chinese adults found that extended-release reduced-mass metformin tablets made in a new Chinese facility ...

A new review explains how dapsone remains central to leprosy treatment while its metabolism drives anemia, methemoglobinemia and hypersensitivity risks.

A long-acting engineered version of the amphibian peptide PGLa-AM1, called PGLa-ABD-AFF, showed a roughly 47-hour half-life and improved glucose control, ...

A new review maps how liquid chromatography–tandem mass spectrometry now quantifies drugs, metabolites, genotoxic impurities and proteins across every stage ...

A comprehensive review of naloxone's chemistry, receptor pharmacology and clinical pharmacokinetics explains why the lifesaving opioid antagonist acts so quickly ...

A new review argues that veterinary drug residues persist through cooking and fermentation, while emerging detection technologies remain too immature ...

A harm reduction journal article outlines a practical framework for dissolving psychoactive powders in sterile saline and delivering them with ...

A new Fc-free CLDN18.2 × CD3 bispecific antibody called AHT-102 showed dose-dependent tumor suppression, tumor-selective tissue distribution, and no systemic ...