Early Gastric Carcinoma with Lymphoid Stroma Shows Lower Metastasis and Higher Survival
A multicenter study reveals that early gastric carcinoma with lymphoid stroma carries a significantly lower rate of lymph node metastasis ...
Tag: PD-L1
Hybrid Nanoparticles Restore Brain Tumor Macrophage Phagocytosis in Cell Culture Models
Engineered exosome-liposome hybrid nanoparticles targeting CSF1R and PD-L1 stimulate macrophage phagocytosis across several brain cancer cell models in vitro, though ...
AI biomarkers show promise for predicting cancer immunotherapy response, review finds
A new review finds AI-derived biomarkers show promising, though variable, performance in predicting cancer immunotherapy response across tumor types.
Circular RNA CD47 Promotes Lung Cancer via Immune Axis
A new study reveals that circular RNA CD47 promotes non-small cell lung cancer progression and immune evasion by stabilizing PD-L1 ...
Plasma extracellular vesicle immunoassay maps immune checkpoint proteins in breast cancer
Researchers developed a multiplexed immunoassay that measures immune checkpoint proteins on the surface of plasma extracellular vesicles and found generally ...
Genetic and Global Burden Data Point to Lipid-Immune Targets in Gynecological Cancers
A combined analysis of global disease data and Mendelian randomization identifies lipid species and immune traits with putative causal links ...
Air Pollutants and Tobacco Carcinogens Drive Colon Cancer via Metabolic Reprogramming
Researchers uncover how fine particulate matter and tobacco carcinogens cooperate with glucose to accelerate colorectal cancer growth through macrophage-driven immune ...
TAM receptors and STAT–SOCS signaling shape the immune landscape of thymic epithelial tumors
A new integrative analysis links TAM receptor and STAT–SOCS signaling to immune infiltration patterns in thymic epithelial tumors.
MRI signal patterns hint at immune landscape of liver cancer in exploratory study
An exploratory study found that arterial wash-in on dynamic contrast-enhanced MRI was inversely correlated with CD3-positive stromal lymphocyte infiltration in ...
Tumor TNF-α Drives CCL4-Producing Neutrophils Linked to Immunotherapy Resistance in Lung Cancer
A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...
Rare Sarcoma Arising From Castleman Disease Tied to Pemphigus and Poor Survival
A six-case retrospective study found follicular dendritic cell sarcoma arising from Castleman disease was frequently complicated by paraneoplastic pemphigus and ...
Immune Cells Skew Toward Inflammation in Children With Newly Diagnosed ITP
A case-control study of 32 children with newly diagnosed immune thrombocytopenia found a pro-inflammatory shift in circulating monocyte-macrophage polarization and ...
Lactate Drives Immune Evasion in Pancreatic Cancer via TRMT6-SIRT5 Axis
A new study reports that lactate in the pancreatic tumor microenvironment promotes metabolic reprogramming and PD-L1 upregulation through the TRMT6-SIRT5 ...
AI pathology scoring flags longer survival on pembrolizumab in metastatic triple-negative breast cancer
An AI-based digital pathology assessment of PD-L1 identified metastatic triple-negative breast cancer patients with longer progression-free survival on pembrolizumab in ...
Extracellular vesicles emerge as dual players and tools in cancer immunotherapy
A new review describes how tumor-derived exosomes suppress immunity while immune-cell-derived vesicles boost antitumor responses, highlighting exosome-based vaccines and biomarkers.
Circulating tumor cells reveal immune escape tricks that may guide immunotherapy
A new review maps how circulating tumor cells survive immune attack in the bloodstream and outlines what evidence is still ...
Ancient Immune Checkpoint in Zebrafish Reveals How Bacteria Hijack T Cell Metabolism
Scientists studying zebrafish have identified a previously underappreciated immune checkpoint that appears to represent an ancient forerunner of the mammalian ...
CT83 Protein Marks Triple-Negative Breast Cancer, but Its Aggressive Links Prove Indirect
A study of 222 breast cancer patients found CT83 expression in nearly half of tumors, with its ties to aggressive ...
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
PD-L1-Targeted Lutetium-177 Radiotherapy Shrinks Triple-Negative Breast Tumors in Mice
Radiolabeled atezolizumab with lutetium-177 significantly reduced tumor volumes and extended median survival in a mouse model of triple-negative breast cancer.
