Blood Inflammation Markers Track Gut Microbe Loss and Predict Sepsis Survival
A prospective single-center cohort study of 215 septic adults links elevated serum MCP-1, GDF-15, PCSK9, and NLRP3 to reduced fecal ...
Tag: PCSK9
Computational study ranks Andrographis diterpenoids at the PCSK9–LDLR interface
A computational study of six Andrographis paniculata diterpenoids found that andrograpanin, though not the top docking scorer, engaged the broadest ...
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Cholesterol Drug Alirocumab Shields the Heart From Alcohol Damage in Rat Study
A new GeroScience study shows that weekly alirocumab, an approved PCSK9 inhibitor, protected rats from alcohol-induced cardiac dysfunction, fibrosis, and ...
Precision Gene Editing: A New Hope for Heart Health
Hypercholesterolemia, characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, poses a significant risk factor for atherosclerotic cardiovascular disease (ASCVD). This ...
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Imaging Reveals Human Pericyte Fate in Mouse Muscle
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Dual Bacillus Probiotic Yields Softer Stool and Targeted Immune Shifts in Dogs