Counting the Clock: Time-to-Event Analysis Reshapes Early Parkinson’s Disease Trials
A new time-to-event analysis of early Parkinson's disease trials shows that large, clinically meaningful worsening thresholds can be detected within ...
Tag: Parkinson’s disease
Antioxidant Protein Thioredoxin-1 Reshapes Oligodendrocyte Lineage Cells in Parkinson’s Model
A new study shows that the antioxidant protein thioredoxin-1 regulates the expansion of oligodendrocyte lineage cells and the accumulation of ...
One Nanopore Panel Reads Out Parkinson’s Genes and Repeat Expansions Together
Researchers have built a 564-gene nanopore adaptive sampling panel that detects Parkinson's disease variants, structural rearrangements, and repeat expansions in ...
Massive Parkinson’s Genetics Study Confirms Rare Gene Variants Raise Disease Risk
New data from the 8,660-participant ROPAD cohort corroborate that ITSN1 loss-of-function variants raise Parkinson's disease risk five- to fifteen-fold, while ...
Large Parkinson’s Study Confirms Rare ITSN1 Gene Variants Raise Disease Risk
An analysis of 8,660 genetically characterized Parkinson's patients from the ROPAD study confirms that heterozygous loss-of-function variants in the ITSN1 ...
Scientists Map the Road to Better Stem Cell Brain Repair for Parkinson’s Disease
A new review in npj Parkinson's Disease examines the strategies needed to improve survival, differentiation and functional integration of stem ...
Synapse-Scanning PET Tracer Emerges as a Window Into Parkinson’s Disease Brain
A systematic review of seventeen studies finds that PET imaging of the synaptic vesicle glycoprotein 2A protein can reveal distinct ...
Hidden LRRK2 Overactivity Found in Parkinson’s Patients Without Known Mutations
A new study finds that about fourteen percent of Parkinson's patients without recognised pathogenic mutations show LRRK2 pathway activation as ...
Sleep Changes in Parkinson’s Disease May Signal More Than Symptoms
A new letter in the Journal of Clinical Sleep Medicine argues that sleep changes in Parkinson's disease should be read ...
Long-Read Sequencing Achieves Near-Perfect Detection of Mitochondrial DNA Variants Linked to Parkinson’s Disease
A validated PacBio HiFi long-read sequencing workflow detects low-frequency mitochondrial DNA heteroplasmy with near-perfect accuracy and reveals dynamic variant trajectories ...
Smartphone tests track early Parkinson’s motor decline over two years
A two-year Czech study used biweekly smartphone tasks to detect subtle motor progression in people with isolated REM sleep behavior ...
Hidden RNA Switches in the Human Brain Reveal New Genetic Routes to Alzheimer’s and Parkinson’s Disease
A single-cell atlas of alternative polyadenylation across two million human brain cells reveals a hidden genetic regulatory layer that explains ...
One in Three Parkinson’s Patients Faces Cognitive Decline, Landmark Analysis Finds
A meta-analysis of over 103,000 Parkinson's disease patients finds cognitive impairment affects roughly one in three, with orthostatic hypotension, diabetes, ...
Weight-Loss Surgery Linked to Sharply Lower Dementia and Parkinson’s Risk
A large matched cohort study of US health records finds that bariatric surgery is associated with substantially lower incidence of ...
Slowed Movements in Parkinson’s Stem From Underscaled Motor Commands, Not Broken Neural Wiring
High-density EMG recordings show that people with Parkinson's disease can generate normal neural drive to muscle but issue underscaled, fragmented ...
Sleep Disorder and Memory Problems May Signal Parkinson’s Years Before Diagnosis
A large All of Us study finds that REM sleep behavior disorder, mild cognitive impairment, and orthostatic hypotension are the ...
AI Ensemble of Vision Transformers Detects Voice Disorders With Record Accuracy
Researchers in Kerala combined DinoV3, EVA-02, and MaxViT vision transformers into a boosted, calibrated voting ensemble that detects six laryngeal ...
How one assay turned prion detection into a revolution across neurodegeneration
A new review in Acta Neuropathologica chronicles how Byron Caughey's development of the RT-QuIC assay revolutionized prion detection and seeded ...
Scientists Watch Proteins at Work Inside Intact Mitochondria Using NMR
Researchers have developed an electroporation-based NMR method that delivers labeled proteins into intact mitochondria, enabling atomic-resolution observation of alpha-synuclein membrane ...
AI Reads Brain Scans Two Ways at Once to Gauge Neurological Disease Severity
A new dual-stream deep learning framework fuses spatiotemporal brain activity with dynamic functional connectivity to classify neurological disease severity from ...
