TMCC2 Suppresses Osteosarcoma Growth and Connects to M1 Macrophage Responses
A laboratory study shows TMCC2 suppresses osteosarcoma growth across cellular and mouse models while correlating with M1-like macrophage responses.
Tag: Osteosarcoma
Scaffold-Free Cell Ring Organoids Improve Preclinical Tumor Modeling and Reduce Animal Use
Biomedical researchers have developed scaffold-free self-assembled cell ring organoids that achieve superior tumor uniformity and engraftment rates in preclinical osteosarcoma ...
Periplocin Kills Osteosarcoma Cells by Driving Necroptosis and Pyroptosis
A new Biology Direct study shows that periplocin suppresses osteosarcoma cell proliferation and tumor growth in preclinical models by inducing ...
Smart Materials and 3D Printing Move Tissue Engineering Toward Functional Validation
An editorial on a Frontiers Research Topic argues that smart biomaterials and additive manufacturing must be tied to measurable, reproducible ...
Circular RNA CircMAP2K4 Drives Osteosarcoma Growth via the miR-515-5p/G3BP2 Axis
Researchers report that the circular RNA circMAP2K4 promotes osteosarcoma progression by sponging miR-515-5p and derepressing G3BP2, and that it is ...
Research report: POSTN+ tumor-associated endothelial cells promote and predict pulmonary metastasis in osteosarcoma
Researchers identified a POSTN-expressing tumor-associated endothelial cell subset that promotes and predicts pulmonary metastasis in osteosarcoma.
Splicing protein LSM5 linked to aggressive growth in osteosarcoma cells
An integrative analysis finds the splicing protein LSM5 over-expressed across cancers and linked to cell-cycle progression, migration and shorter survival ...
Long Non-Coding RNA LINC01140 Shows Dual Roles Across Human Cancers, Review Finds
A new review in Cell Division finds that the long non-coding RNA LINC01140 acts as an oncogene in some cancers ...
Family Trees of Irish Wolfhounds Reveal Few Ancestors and Hidden Inbreeding
A reconstructed pedigree of 2,343 Irish Wolfhounds shows that a few influential ancestors dominate the breed and that incomplete family ...
Machine Learning Model Links Tumor Cell Malignancy to Osteosarcoma Outcomes and Flags OPN3 as a Drug Target Candidate
A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...
Extracellular vesicles emerge as dual players in tumor immunity and drug resistance
A new editorial argues that extracellular vesicles both drive tumor adaptation and drug resistance and offer promising platforms for antitumor ...
Third Course of Stereotactic Radiotherapy Shown Safe in Spinal Osteosarcoma Case
A case report from Warsaw describes the first documented second reirradiation with stereotactic body radiotherapy in metastatic osteosarcoma, achieving a ...
Patient-Balanced Single-Cell Analysis Separates Recurring and Patient-Restricted Tumour Programmes in Osteosarcoma
A patient-balanced single-cell study of osteosarcoma resolved seven malignant programmes, separating a moderately recurrent extracellular-matrix state from a chondro-hypoxia programme ...
Ginsenoside RK3 triggers ferroptosis in osteosarcoma cells and boosts doxorubicin response
A preclinical study reports that ginsenoside RK3 suppressed osteosarcoma growth in cells and mouse xenografts by downregulating PRMT5, promoting GPX4 ...
Osteosarcoma rewires matrix signaling as disease progresses
A 2026 Review argues that osteosarcoma survival and lung spread depend on stage-specific rewiring of extracellular-matrix signaling rather than one ...
Review assesses miRNA nanocarriers for osteosarcoma
A 2026 review finds that miRNA nanocarriers may help overcome delivery barriers in osteosarcoma, while emphasizing unresolved safety, manufacturing, regulatory ...
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
Thai researchers outline early-phase trial of a new GD2 CAR-T product
A published protocol describes a planned first-in-human trial of an investigational product: an autologous chimeric antigen receptor T-cell therapy designed ...
Single-cell and bulk transcriptomic characterization of the osteosarcoma microenvironment reveals lineage-specific programs and inflammatory differences associated with metastasis
Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...
Stem Cell Gene Sox2 Study in Bone Cancer Retracted Over Manipulated Images
The journal Pathology & Oncology Research has retracted a 2018 osteosarcoma study after the authors reported improper image cropping, with ...
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