Machine learning predicts human oral drug bioavailability from animal data
A machine learning pipeline trained on 192 FDA-approved compounds predicts human oral bioavailability with an R2 of 0.766, outperforming previous ...
Tag: Oral bioavailability
From Nanoemulsion-Templated Drug Nanoparticles to Machine Learning Property Prediction: The Research Path of Lucas Attia
An AAPS Open editorial spotlights chemical engineer Lucas Attia, whose PhD work matured nanoemulsion templating for drug nanoparticle formulation and ...
Plant Triterpenoids Show Promise Against Obesity, But Human Evidence Remains Thin
A Frontiers in Aging review argues that natural triterpenoids such as celastrol, ursolic acid and ginsenosides could complement existing obesity ...
Computational Screening Points to Two Quinoline Candidates Against Tuberculosis and Resistant Infections
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
Molecular Cage Supercharges Blood-Thinner Absorption and Calms Inflammation in Mice
A cucurbituril host–guest formulation of ticagrelor boosts solubility, doubles systemic exposure, and shifts macrophages toward an anti-inflammatory state in preclinical ...
Tiny Capsules, Big Relief: Flavonoid Nanoparticles Aim Directly at Inflamed Guts
A new Perspective in npj Science of Food lays out a four-pillar design framework for wrapping anti-inflammatory flavonoids in nanoparticles ...
Exploring Liquisolid Powders of Andrographis Paniculata
In a remarkable new study, researchers have delved into the intricacies of liquefied solid powders derived from the traditional medicinal ...
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