Urial Genome Assembly Pinpoints Candidate Structural Variants Linked to Sheep Evolution
A high-quality Urial genome assembly reveals candidate structural variants and gene families linked to sheep body-size evolution.
Tag: Nanopore Sequencing
Targeted Nanopore Sequencing Detects Drug-Resistant Tuberculosis Mutations in Cultured Samples
A proof-of-concept targeted Nanopore sequencing assay demonstrated high accuracy for detecting drug-resistant tuberculosis mutations in culture, but variable coverage limited ...
Nanopore Method Maps Active tRNAs During Cellular Stress
A new nanopore sequencing method called tRIBO-seq distinguishes between ribosome-associated and total tRNAs, revealing distinct dynamics under stress.
Mosquito Vectors in São Paulo Forest Fed Chiefly on Humans
Following a yellow fever outbreak in São Paulo State, researchers found that 76.6 percent of identified mosquito blood meals came ...
One Blood Test, Two Answers: Nanopore Sequencing Reads Genes and Methylation Together
Nanopore long-read sequencing that simultaneously reads genetic variants and DNA methylation resolved three difficult KMT2B-related dystonia diagnoses, confirming one uncertain ...
Nanopore Sequencing Delivers Full Pediatric Brain Tumor Workup in a Single Assay
A retrospective study of 20 pediatric CNS tumors found long-read nanopore sequencing matched methylation arrays for copy-number profiling and tumor ...
Venue, not beer, shapes the microbes lurking in draught no-alcohol beer
A nanopore sequencing study of draught no- and low-alcohol beers in Nottingham pubs found that the dispensing venue, not the ...
Nanopore RNA Sequencing Method Yields Candidate Motifs for Three RNA Modifications
A computational framework applied exponential population analysis to direct RNA sequencing data from HEK293T cells and human blood to identify ...
Nanopore sequencing identified pathogens in eight culture-negative infections
An eight-patient case series found that nanopore amplicon sequencing identified fungi or bacteria in culture-negative infections, with targeted treatment followed ...
Long-Read DNA Sequencing Uncovers Hidden Cancer Drivers Missed by Standard Tests
University of Michigan researchers used long-read nanopore sequencing to resolve hidden cancer-driving alterations in tumors and to trace the origin ...
Multiomic map of methylation in Mycoplasma hyorhinis
A multiomic study of Mycoplasma hyorhinis SK76 links specific methyltransferases to genome-wide DNA methylation patterns but does not directly test ...
New Rain Frog Species Uncovered in Ecuador’s Cloud Forests Reveals Hidden Evolutionary Radiation
Scientists have described a new rain frog species from Ecuador's Cerro Candelaria and revealed that the upper Rio Pastaza watershed ...
RNA 5-methylcytosine cancer biomarkers face a measurement gap, not a biology gap
A new review argues that the slow clinical translation of RNA 5-methylcytosine cancer biomarkers stems from a lack of analytically ...
Hybrid Genome Assembly Reveals Effector Arsenal of White Rust Pathogen in Indian Mustard
Researchers have sequenced the complete genome of an Indian isolate of the white rust pathogen Albugo candida, revealing 13,715 genes ...
Deadwood Fungi Follow the Tree: Legacy Effects Persist as Logs Break Down
A long-read eDNA study in an old-growth Belgian beech forest shows that individual tree identity persists as the strongest driver ...
The Methylation Test That Decides Brain Cancer Treatment Faces a Reckoning
A new Mayo Clinic review in the Journal of Neuro-Oncology examines how MGMT promoter methylation guides brain tumor treatment, why ...
Nanopore Sequencing Spots Deadly Fungal Bloodstream Infections in Hours, Not Days
Researchers at Chiba University have developed a nanopore sequencing workflow that identifies fungal species in blood culture samples within about ...
Deep Learning Tool Reads RNA Tails Straight From Nanopore Signals
A new deep learning framework called PolyAnalysis estimates RNA poly(A) tail lengths directly from raw nanopore sequencing signals and profiles ...
Novel FP-NSA Technique Enhances Virus Surveillance in Humans, Animals
In a groundbreaking advancement in the field of virology, researchers have introduced an innovative technique known as multiplex family-wide polymerase ...
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