Tag: Myc

A new mini review describes how the polyamine spermidine can both fuel colorectal cancer growth through the MYC–ODC–eIF5A circuit and, ...

Deleting the Myc gene in mouse granulosa cells disrupts glycerophospholipid metabolism, damages oocyte spindles and causes female infertility.

A new study reports that elevated ACOT7 promotes malignant phenotypes in head and neck squamous cell carcinoma by raising arachidonic ...

Researchers used optogenetic melanopsin stimulation in HeLa cells to show that the timing pattern of light-evoked calcium signaling selectively shapes ...

A large integrated transcriptomic study shows that rising cancer stemness tracks prostate cancer progression, lineage plasticity, therapy resistance, and poor ...

A new review argues that transcriptional CDK inhibitors, especially CDK9 blockers, could simultaneously target oncogenic transcription in metastatic tumor cells ...

A Drosophila study shows that an elevated Myc-to-Max ratio, rather than absolute MYC abundance, switches eye progenitors toward a wing ...

A study in Journal of Translational Medicine shows that the tumor protein stratifin stabilizes PAK1 and activates MYC-driven NECTIN2 expression, ...

Pre-osteoblast-derived migrasomes delivered miR-21a-5p to inhibit osteoclast differentiation in cell assays and reduced bone loss in an ovariectomy mouse model.

A new perspective article argues that CBM immune signaling complexes regulate the MYC oncogene through transcription, physical binding, and protein ...

A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...

A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...

A single-cell analysis of nearly half a million pancreatic cancer cells shows that continuously evolving clones reshape their DNA to ...

A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...

New research shows that high-risk Group 3 and Group 4 medulloblastoma cells accumulate cholesterol ester-rich lipid droplets that support energy ...

New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...

A pan-cancer single-cell atlas of nearly 900,000 cells shows that bone metastases from ten cancer types share convergent malignant programs ...

A new review argues that host chromatin architecture and three-dimensional genome rewiring, not just HPV oncoproteins, stabilize malignant states and ...

Lung adenocarcinoma (LUAD) presents a significant challenge to clinicians and researchers alike, as the prognosis for patients diagnosed at late ...