4-Octyl itaconate delays lupus onset by suppressing STING signaling
A new study in Cell Death Discovery shows that 4-octyl itaconate delays lupus onset in mice by promoting tolerogenic dendritic ...
Tag: murine model
FOXO1 Governs Epithelial Barrier Integrity by Regulating Adherens Junction Complexes
Researchers found that FOXO1 drives rapid bacteria-induced epithelial barrier failure through the spatial regulation of the E-cadherin–β-catenin complex independent of ...
NLRP3 Inflammasome Drives Airway Junction Dysfunction in Murine Lung Injury Model
Inhibition of the NLRP3 inflammasome restores adherens junction proteins and alleviates pulmonary inflammation in a murine acute lung injury model.
Superoxide in injured mouse lungs imaged directly by low-frequency EPR
Low-frequency EPR imaging of excised mouse lungs reveals that blood superoxide does not always reflect lung redox status in acute ...
Vinpocetine Eases Lung Inflammation in Mice by Damping Pentraxin 3
A mouse study of mixed granulocytic asthma suggests the drug vinpocetine reduces airway inflammation by lowering levels of the immune ...
Cerium–Curcumin Complex Speeds Wound Closure in Mice, Reaching Complete Healing by Day 10
A chemically synthesized cerium–curcumin coordination complex formulated as a 2% topical ointment achieved complete wound closure in mice by day ...
Mosquito Saliva Protein Fragment Boosts Dengue Virus Replication in Immune Cells
A C-terminal fragment of the Aedes albopictus salivary protein 34k2 binds DENV-2 virions with high affinity and enhances viral replication ...
Brain rewires energy metabolism to protect memory in late-stage sleeping sickness
In a bioluminescent mouse model of late-stage Trypanosoma brucei infection, the brain shifts from glucose to fatty acid and lipid ...
Deadly Fungus Morphs Into Tiny Titanide Cells Under Pressure From the Host
New research in PLOS Biology defines the titanide, a tiny stress-resistant cell type that Cryptococcus neoformans generates from typical yeast ...
Common Plant Compound Rutin Shields Against Deadly Viper Venom Damage in Mice
Orally administered nano-formulated rutin significantly reduced hemorrhage, inflammation, and blood-clotting disturbances in mice envenomed by Bothrops jararaca, even without antivenom.
Tick-Borne Rickettsia Reaches Host Skin Within an Hour of a Bite
A new single-tick feeding model reveals that Rickettsia parkeri is transmitted to host skin within one hour of tick attachment ...
Two Trypanosome Species, Same Parasite Burden, Very Different Fates in Mice
A controlled mouse study shows that Trypanosoma congolense and Trypanosoma brucei produce similar parasite burdens and organ damage but sharply ...
Gut Dysbiosis Links to Skin Immune Responses in Mice
In a groundbreaking study that has the potential to reshape our understanding of autoimmune conditions, a team of researchers led ...
Centella asiatica Extract Enhances Brain Health in Mice
In recent years, scientific investigations into the medicinal properties of various natural extracts have gained momentum, particularly in addressing complex ...
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