Tag: Mitochondrial dysfunction

Chronic kidney disease silently undermines the immune system, leaving patients dangerously vulnerable to infections that healthy bodies shrug off with ...

A new collection of ten studies shows that type 2 diabetes complications arise from an interconnected network of oxidative stress, ...

A new integrative review proposes that bipolar disorder arises from a destabilized feedback network linking stress hormones, mitochondrial energy failure, ...

A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...

A comprehensive review finds that the lipid-lowering drug fenofibrate shows strong clinical evidence for slowing diabetic retinopathy and promising preclinical ...

New research shows that curcumin reduces mutant huntingtin aggregation, restores mitochondrial function, lowers oxidative stress, modulates epigenetic marks and suppresses ...

Researchers have identified the interferon-stimulated protein IFIT3 as a highly dysregulated centromere-proximal protein in fetal Down syndrome cells, showing that ...

New research shows that environmental neurotoxicants damage mitochondria in ways that break down the nuclear pore complex and disrupt nucleocytoplasmic ...

A new review argues that gut-derived short-chain fatty acids, especially butyrate, could protect newborn brains from hypoxic-ischemic injury by breaking ...

A new Nature Metabolism study shows that NADH-reductive stress damages primary human cells mainly through NADPH depletion, and that a ...

A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...

A new in vitro study shows that HFPO compounds marketed as safer PFOA replacements impair human sperm motility, acrosome reaction ...

A multi-omics study in Nature Communications reports a seven-feature blood-based diagnostic panel and a twelve-transcript prognostic signature that diagnose pediatric ...

A mitochondrial-derived peptide called MOTS-c protects retinal blood vessels in diabetic retinopathy by activating the phospholipase PLA2G6 to clear damaging ...

A comprehensive new review in the Journal of Translational Medicine synthesizes the epidemiology, biology, and treatment controversies of ME/CFS, highlighting ...

A multi-platform transcriptomic atlas of the human right ventricle reveals a two-phase progression to failure, with early erosion of protective ...

New research shows that the natural polyamine spermidine protects pig ovarian granulosa cells from copper overload-induced cuproptosis by suppressing miR-194a-5p ...

A Mayo Clinic study of irradiated mice shows that males develop inflammatory dilated cardiomyopathy and fibrosis after cardiac radiation while ...

A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...

A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...