Transcranial Laser Therapy Promotes Long-Term Functional Recovery in Neonatal Rats
A study in neonatal rats found that early transcranial low-level laser therapy reduced neural tissue damage and supported functional and ...
Tag: Microglial activation
Brain Waste Clearance Links Disrupted Sleep Architecture to Progressive Neurological Proteinopathies
A narrative review synthesizes clinical neuroimaging and biophysical evidence linking psychiatric sleep architecture disruptions to impaired glymphatic waste clearance and ...
Review Examines Clonal Haematopoiesis as Potential Contributor to Postoperative Neuroinflammation
A hypothesis-generating review examines whether age-related clonal haematopoiesis intensifies systemic inflammation and cognitive dysfunction following cardiac surgery.
Costunolide Suppresses Microglial Neuroinflammatory Activation by Targeting G3BP1 and APRT
Costunolide reduces inflammatory activation in cultured microglia partly by binding G3BP1 and APRT to suppress NF-κB signaling.
Late-Gestational Sleep Loss Drives Aggression in Male Mice Through Hypothalamic Inflammation
Maternal sleep deprivation during late pregnancy induces heightened aggression in adult male mice through ventromedial hypothalamic interleukin-6 signaling, an effect ...
Sinomenine Regulates Microglial PCK1 and Bioenergetics in Vascular Dementia Model
Researchers integrated multi-omics analyses and cellular assays to demonstrate that sinomenine modulates PCK1-associated immunometabolic pathways and attenuates inflammatory stress in ...
Brain Alterations and Central Sensitization Drive Painful Diabetic Peripheral Neuropathy
A comprehensive scientific review synthesizes structural, functional, and neurochemical changes across the brain that sustain persistent painful diabetic peripheral neuropathy.
Loss of CADM3 worsens amyloid buildup and synaptic damage in Alzheimer’s mice
A new study reports that CADM3 expression drops in human Alzheimer's brains and that its genetic loss worsens amyloid deposition, ...
Varenicline’s molecular mechanisms in neuropsychiatric disorders reviewed
A new review examines how the α4β2 nicotinic receptor agonist varenicline might act on molecular pathways involved in neuropsychiatric disorders.
Review links sevoflurane exposure during development to neuroinflammatory pathways linked with neurotoxicity
A mini review finds that preclinical evidence links repeated or prolonged sevoflurane exposure during development with neuroinflammation, microglial activation and ...
Brain Inflammation Emerges Years Before Symptoms in Spinocerebellar Ataxia Type 3, Landmark Imaging Study Finds
A large multimodal imaging study reveals that neuroinflammation in the brainstem of SCA3 mutation carriers appears years before ataxia onset, ...
Poor Blood Flow to the Brain May Steer Early Tau Pathology Toward Vulnerable Regions
A new mouse study shows that early chronic cerebral hypoperfusion spatially biases tau pathology and drives neuroinflammation at the onset ...
Common Antibiotic Minocycline Shows Glimmer of Benefit for Stroke Recovery Quality of Life
A prespecified analysis of the EMPHASIS trial in China finds that minocycline may improve patient-reported quality of life after acute ...
Remote Astrocytes Drive White Matter Repair
In the intricate landscape of central nervous system (CNS) injury, the interplay between cellular actors governs the trajectory from damage ...
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