Review Frames Liquid-Liquid Phase Separation as Key Target in Tumor Evolution
A review in Molecular Cancer outlines how liquid-liquid phase separation drives tumor evolution and provides programmable strategies for precision cancer ...
Tag: liquid-liquid phase separation
SMARCAL1 condensates drive radioresistance and immunosuppression in tumours
A new study shows that SMARCAL1 forms nuclear condensates that reprogram chromatin and methionine metabolism, weakening radiotherapy and immunotherapy responses.
Faster Algorithms Decode the Folding Rules of RNA Triplet Repeats
New algorithms predict the folding and interactions of repetitive RNA strands far faster than previous methods, revealing which triplet patterns ...
Phase Separation Is an Evolvable Trait, Argues New Evolutionary Framework
A new perspective argues that liquid–liquid phase separation should be studied as an evolvable molecular phenotype shaped by natural selection.
Crowded molecular environments steer synthetic DNA droplet self-assembly
Macromolecular crowding with polymers such as PEG promoted the formation of synthetic DNA nanostar droplets and allowed researchers to control ...
RNA-Binding Protein VCX3A Drives Spermatogonial Cell Proliferation and Motility Through Splicing Control
A new Cell & Bioscience study shows that the RNA-binding protein VCX3A cooperates with the splicing regulator KHDRBS1 to promote ...
Phase-Separating Condensates Emerge as Drivers of Glioblastoma Progression and Drug Resistance
A review in Acta Neuropathologica Communications describes how aberrant liquid-liquid phase separation may drive glioblastoma progression and therapy resistance, and ...
New Study Identifies UBA1 as a Key Biomarker in Multiple Myeloma
A new study identifies UBA1 as a primary candidate biomarker for multiple myeloma by integrating ubiquitination and liquid-liquid phase separation ...
Tiny Droplets Inside Cells Could Decide Whether Cancer Therapy Works
A new review in Molecular Cancer synthesizes how liquid-liquid phase separation shapes radiosensitivity, immune evasion, and treatment resistance in cancer.
Mutations Give RNA Droplets Their Own Genes, Vacuoles and Movement
Researchers have shown that RNA droplets trap their own DNA templates, and that even low rates of mutation produce stable ...
Transient pH Triggers Vacuole Formation in Condensates
In a significant breakthrough in the field of chemical engineering and biomolecular condensates, researchers have uncovered the critical role of ...
Intersectin-Endophilin Condensates Prime Synaptic Vesicle Release
In the intricate landscape of neuronal communication, the seamless transmission of signals relies on the precise and rapid replenishment of ...
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