ITGA5 speeds diabetic wound healing by easing mitochondrial iron overload
A new study reports that restoring the integrin subunit ITGA5 accelerated wound closure in diabetic mice by protecting endothelial mitochondria ...
Tag: Iron Metabolism
Perforin Kills Cancer Cells Alone, Without Granzymes, Study Finds
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...
Genetic Study Links Iron-Cell Death Genes to Leukemia Risk via Immune Cells
A Mendelian randomization study finds that ferroptosis-related genes influence acute myeloid leukemia risk directly and indirectly through specific immune cell ...
Rabies virus matrix protein stabilizes RGS4 to curb ferroptosis and aid replication
Rabies virus matrix protein stabilizes RGS4 through incomplete autophagy, suppressing neuronal ferroptosis and supporting viral replication.
Research report: Unraveling the iron grip: ferroptosis and its role in cardiovascular diseases
A new open-access review in Cell Biology and Toxicology examines how ferroptosis, an iron-dependent form of cell death, may contribute ...
Excess cysteine releases iron, overwhelming mitochondria and killing cells
A CRISPR screen and laboratory experiments show that excess cysteine releases iron from ferritin, damages mitochondria and triggers cell death.
Ferroptosis framework maps how iron-driven cell death could be pushed or blocked for precision drugs
A new Perspective proposes a unified pharmacological-toxicological framework treating ferroptosis, mitochondrial stress and redox imbalance as one axis governing both ...
Astragaloside IV Emerges as a Candidate Ferroptosis Link in Heart Hypertrophy
Astragaloside IV reduces pathological cardiac hypertrophy and suppresses ferroptosis in separate models, but direct experiments are needed to establish whether ...
Mitochondria emerge as the central hub linking cell death and metabolism in gum disease
A new review proposes that mitochondrial collapse drives a self-reinforcing cycle linking ferroptosis and metabolic reprogramming in periodontitis, opening the ...
Iron, Inflammation, and a Deadly Paradox: Rethinking Cancer Wasting Through Ferroptosis
A new iScience review argues that ferroptosis, an iron-driven form of cell death, links tumor and immune signals to muscle ...
Scientists Map the Iron Recycling Switch That Decides Whether Cells Live or Die
A new review in the Journal of Translational Medicine maps how NCOA4-mediated ferritinophagy controls iron release and ferroptosis, cataloguing small-molecule ...
Reevaluating Myeloproliferative Neoplasms: Iron and JAK2 Insights
In a groundbreaking study, researchers González-Resina, España-Fernández de Valderrama, and Montañés, along with their team, delve into the intricate world ...
