Tag: immunotherapy

The Alliance for Clinical Trials in Oncology marks Breast Cancer Awareness Month with eight active trials spanning treatment de-escalation, survivorship ...

A single dose of a CCR5/CD3 bispecific antibody depleted the SIV reservoir in infant macaques, producing durable aviraemia and apparent ...

A new review explains how tumor ablation triggers a transient immune response in liver cancer and why combining it with ...

St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...

A pooled analysis of 19 studies finds that neoadjuvant apatinib-based regimens achieve a 21 percent pathologic complete response rate in ...

A post hoc analysis of the Neo-PLANET trial found that higher spleen metabolic activity on pre-treatment FDG PET scans predicts ...

A review in Genes & Diseases maps how VHL loss drives metabolic reprogramming in clear cell renal cell carcinoma and ...

A longitudinal study of 155 lymphoma patients found that older adults recovered memory function after CAR T-cell therapy while younger ...

New awards from the AACR, Department of Defense and National Cancer Institute will fund enhancer hub research, ovarian cancer immunotherapy, ...

New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.

Wistar Institute researchers found that the neurotransmitter neuromedin U suppresses T cell infiltration at the earliest stage of neuroendocrine prostate ...

A new six-gene signature derived from weighted gene co-expression network analysis predicts breast cancer survival and characterizes the tumor immune ...

A new study links baseline IFN-γ-based NK cell activity to ex vivo expansion capacity of autologous NK cells, offering a ...

A new Oncoscience perspective maps the 2025–2026 glioblastoma clinical trial pipeline across four mechanistic domains, showing how biomarker-guided selection and ...

Single-cell sequencing reveals that self-derived and donor-derived exhausted T cells in acute myeloid leukemia run on different transcriptional programs, with ...

A phase I trial found that a CCL21-engineered dendritic cell vaccine combined with pembrolizumab safely increased T cell infiltration in ...

New MD Anderson studies report a Phase 3 immunotherapy advance in EGFR-mutant lung cancer, a dual role for B7-H3 in ...

A new MD Anderson study finds that pre-existing immune rejection and the intrinsic fitness of donor-derived CAR T cells determine ...

UChicago Medicine has launched a first-of-its-kind investigator-initiated clinical trial of a fully on-site manufactured T-cell receptor therapy engineered to target ...

A new study reveals that the protein GSDMB enhances anti-PD-1 immunotherapy in bladder cancer by driving Sema7a-mediated recruitment and activation ...