Tag: Immune checkpoint inhibitors

A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...

A real-world study of 178 esophageal cancer patients shows that residual tumor grade and post-treatment lymph node status, especially ypN3, ...

A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...

A meta-analysis of 17 studies finds that Helicobacter pylori infection is associated with worse overall and progression-free survival in cancer ...

A new review in Medical Oncology argues that tumor ablation can act as an in situ vaccine whose systemic power ...

A large analysis of melanoma patients treated with immune checkpoint inhibitors finds that 12 percent develop significant neurotoxicity, often within ...

A new study shows that a simple index combining hemoglobin and the albumin-to-alkaline phosphatase ratio can predict survival outcomes in ...

A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...

A large target trial emulation found that cancer patients on SSRIs while receiving immune checkpoint inhibitors had significantly lower two-year ...

A new review in Medical Oncology argues that simultaneously inducing the iron-driven cell death ferroptosis and the copper-driven cuproptosis, tuned ...

New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their tumor-killing activity and ...

An analysis of nearly half a million clinical trials and real-world data from over 91,000 patients reveals that immune-related side ...

An exploratory study in BMC Medicine presents a three-dimensional NIR-II fluorescence molecular tomography system fused with X-ray CT that quantifies ...

A new review in Medical Oncology maps how the tumor microenvironment and gut microbiome drive resistance to immune checkpoint inhibitors ...

A pooled analysis of four clinical trials finds that liver metastases are a strong negative prognostic factor for chemotherapy-treated pancreatic ...

A matching-adjusted indirect comparison of two landmark trials suggests retifanlimab significantly prolongs progression-free survival compared with avelumab in metastatic Merkel ...

A controlled in vitro study shows irreversible electroporation induces stronger dendritic cell activation and T cell proliferation than cryoablation or ...

A new review in the Journal of Translational Medicine maps how non-small cell lung cancer rewires lipid metabolism to fuel ...

A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...

A new review finds growing preclinical evidence that the gut microbiome can influence glioblastoma immunity, while warning that human evidence ...