KISS1 gene variants linked to PCOS risk across multiple populations, review finds
A systematic review of 26 studies links KISS1 gene polymorphisms, particularly rs4889, to polycystic ovary syndrome susceptibility and hormonal dysregulation ...
Tag: Hyperandrogenism
Alcohol, nicotine and cannabis each reshape PCOS biology in distinct ways, review finds
A review of 87 studies links chronic alcohol use, nicotine exposure and weekly cannabis consumption to distinct hormonal and metabolic ...
Excessive pregnancy weight gain may shape daughters’ ovarian and metabolic risk
A new review in Frontiers in Endocrinology examines whether excessive gestational weight gain could program daughters' risk of polyendocrine metabolic ...
PCOS reframed as PMOS: fetal programming, epigenetics and puberty’s second hit
A new review proposes that polyendocrine metabolic ovarian syndrome arises from prenatal epigenetic programming that is unmasked by puberty and ...
PCOS Phenotypes Show Similar ART Pregnancy Outcomes, Study Finds
A retrospective study of 1,377 PCOS patients undergoing ART found comparable pregnancy and neonatal outcomes across the four Rotterdam phenotypes, ...
Puberty Upends Care for Teens With Congenital Adrenal Hyperplasia
A new review details how puberty complicates the diagnosis, treatment and psychosocial wellbeing of adolescents living with congenital adrenal hyperplasia.
Gut Microbes Take Center Stage in the Renamed Ovarian Syndrome PMOS
A new review proposes an integrated gut–metabolism–endocrine–ovary axis linking gut microbiota dysbiosis to insulin resistance, hyperandrogenism, and ovarian dysfunction in ...
Metabolic Enzyme NNMT Drives Ovarian Hormone Disorder Through Epigenetic Rewiring
New research in Nature Metabolism reveals that the metabolic enzyme NNMT drives hyperandrogenism in polyendocrine metabolic ovarian syndrome by depleting ...
Adolescence Emerges as Decisive Window for Fertility Care in Congenital Adrenal Hyperplasia
A new review maps how congenital adrenal hyperplasia disrupts fertility and psychosexual development in adolescents and argues that early, multidisciplinary ...
Coconut Oil Fatty Acid Shows Promise Against PCOS in Mouse Study
A new mouse study finds that lauric acid, the main fatty acid in coconut oil, partially reverses the hormonal and ...
Obesity Amplifies PCOS Severity, but Lean Women Still Face Serious Metabolic Risks
A meta-analysis of 42 studies and over 5,300 women shows obesity dramatically worsens the hormonal and metabolic profile of polycystic ...
How Gut Bacteria May Drive Insulin Resistance in Polycystic Ovary Syndrome
A new narrative review in Reproductive Sciences argues that gut microbial dysbiosis, endotoxemia, and chronic low-grade inflammation drive insulin resistance ...
Hidden Mental Health Crisis: Women With PCOS Face Sharply Elevated Suicide Risk, Major Analysis Finds
A new meta-analysis of ten studies finds that women with polycystic ovary syndrome show significantly higher rates of depression, suicidal ...
PCOS Gets a New Name and a Radical New Explanation
A major review argues that the newly renamed polyendocrine metabolic ovarian syndrome is a lifelong systems-level disease driven by hypothalamic, ...
Unveiling AKT-LONP1-STAR Axis in PCOS Hyperandrogenism
In an era where scientific advancements are reaching unprecedented heights, understanding the intricate biological systems governing human health remains a ...
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