Genome Sequencing Tracks Mutations in Stem Cells Grown for Months
Whole-genome sequencing of human embryonic stem cells over 40 passages found low mutation burdens dominated by clock-like and oxidative stress ...
Tag: genomic stability
NAT10 enzyme adds ketone-derived tag to histones to speed DNA replication
A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...
ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer
A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why ...
R-Loops: Double-Edged Players in Genome Stability and Disease
In the rapidly evolving landscape of molecular biology, R-loops—a three-stranded nucleic acid structure formed by an RNA:DNA hybrid and a ...
POPULAR NEWS
-
Every Hour of Delay After an Open-Globe Injury Raises Endophthalmitis Risk, Study Finds
-
Cellular Study Links Hepatitis B Mutation to Altered Liver Cell Mechanics
-
Standardized Test Assesses Nutrition Knowledge Among Rural Women in Uttar Pradesh
-
Meta-Analysis Assesses Targeted Therapies for MET-Altered Non-Small Cell Lung Cancer