Gene Mapping Rebounds as Polygenic Risk Scores Hit a Structural Wall
A new Frontiers in Genetics review argues that the NOIA model overcomes a key obstacle to unbiased gene mapping just ...
Tag: genome-wide association studies
Massive UK Biobank reference panel sharpens genetic imputation worldwide
A new haplotype reference panel built from 490,319 UK Biobank genomes beats the widely used TOPMed r3 panel for most ...
Genomics Goes Routine: From Model Labs to Honey Bees, Crops and Wild Populations
A new perspective argues that genomics has shifted from a specialized pursuit of well-funded labs to a routine tool now ...
Geneticists certify 108 high-confidence Alzheimer’s risk signals
A systematic adjudication framework applied to 29 genome-wide studies produced a catalog of 108 high-confidence genetic signals for Alzheimer's disease ...
Two decades of Mendelian randomization mapped: pleiotropy tops the field’s methodological worries
A bibliometric and content analysis of 21,346 Mendelian randomization publications finds horizontal pleiotropy as the most frequently coded methodological challenge ...
Trans-Ancestry Genetic Risk Score Boosts Heart Disease Prediction in Chinese Adults
A new trans-ancestry polygenic risk score built by fusing East Asian and European genome-wide association data markedly improves coronary artery ...
Africa’s genetic diversity could transform global mental health research
A major new review argues that Africa's unmatched genetic diversity, combined with rising mental health needs and growing continental research ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
New Sparse Regression Method Tames Biobank-Scale Genetic Data for Risk Prediction
Researchers have adapted a two-stage sparse regression method called uniLasso to the UK Biobank, producing polygenic risk scores that match ...
Revolutionizing Genome Studies with SECRET-GWAS
In the rapidly evolving field of genomics, the significance of genome-wide association studies (GWAS) cannot be overstated. However, a critical ...
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