Tag: drug resistance

Egyptian researchers found that metronidazole, metformin, and onion extract all suppress Blastocystis growth in lab cultures by disrupting the parasite's ...

The Journal of Experimental & Clinical Cancer Research has issued an editorial expression of concern over image integrity in a ...

Chemists have synthesised a series of sulfonamide-linked 1,2,3-triazole hybrids via click chemistry, with a dichloro-substituted lead showing activity against bacteria, ...

Researchers in China have identified a circular RNA, hsa_circ_0029325, that drives imatinib resistance in chronic myeloid leukemia by upregulating the ...

A new review in Advanced Cancer Research details how post-translational modifications regulate KRAS localization, activity, stability, and degradation, opening fresh ...

University of São Paulo researchers found that fourteen derivatives of an anticancer compound kill Plasmodium falciparum at both the blood ...

New research reveals that Leishmania parasites survive antimony treatment through active transcriptome remodeling, a transient persister state that may pave ...

A new review maps how plant-derived flavonoids attack tuberculosis through multiple molecular mechanisms while outlining the structural features and delivery ...

New laboratory evidence shows the single-dose oral drug acoziborole is as potent against the rarer rhodesiense form of sleeping sickness ...

New research reveals that resistant myeloma cells import putrescine through the transporter SLC45A4, activating HOXA1-driven NF-kappaB signaling with help from ...

A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, ...

Fred Hutch researchers report in Nature that a single transfer RNA, tRNA1Arg(UCU), controls whether prostate cancer cells remain androgen receptor-dependent ...

A seven-year study of more than 2,000 tuberculosis patients at a Rome referral hospital found that extrapulmonary tuberculosis almost always ...

A new review in Molecular Biology Reports maps how the ceramide–S1P balance and ganglioside signaling form a cancer-type-specific lipid code ...

A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...

A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...

A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...

A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...

A five-year, $13.1 million NIH grant will fund engineered, nontoxic Salmonella designed to deliver radiopharmaceutical therapy, viral payloads, and immune-targeting ...

Researchers have functionally characterized CD34/CD123/CD25/CD99-positive leukemic progenitor cells in FLT3-ITD-mutated AML, showing they engraft and reinitiate leukemia in mice and ...