Mango Compound Mangiferin Shows Multi-Stage Activity Against Toxoplasma gondii
A new in vitro and mouse study finds that mangiferin, a mango-derived xanthone, suppresses Toxoplasma gondii adhesion, invasion, and proliferation ...
Tag: drug discovery
Fungal Compound Sapinopyridione Shows Anti-SARS-CoV-2 Activity in Cells
A compound called sapinopyridione from a Botryosphaeria fungus isolated inside Zanthoxylum piperitum inhibited SARS-CoV-2 in infected cells with an IC50 ...
Virtual screening yields two drug candidates that disable c-Myc in colorectal cancer
A multi-stage virtual screening campaign against the c-Myc/Max dimerization interface has identified two small molecules that suppress c-Myc protein, block ...
SADRP: A structurally aware multi-modal framework for drug response prediction
SADRP combines drug topology, chemical-bond information, gene expression and DNA methylation to predict drug sensitivity across cancer cell lines.
Review assesses network pharmacology for herbal medicines in rheumatoid arthritis
A review of network-pharmacology studies found that herbal medicines for rheumatoid arthritis repeatedly converged on inflammatory and immune pathways, but ...
Patient-derived cancer models expand dependency maps but expose new limits
Hundreds of patient-derived cancer models expanded dependency mapping and revealed vulnerabilities linked to mutations, cellular states and treatment history, while ...
Targeted Lysosomal Degradation: From Receptor Hijacking to Endolysosomal Routing
A review identifies post-endocytic routing as the decisive step in targeted lysosomal degradation and proposes a five-tier framework for verifying ...
In silico study identifies two benzofuran candidates for selective MAO-B inhibition
A multilayered in silico study of 37 synthesized benzofuran derivatives nominated compounds 10 and 16 as candidates for selective MAO-B ...
Hupehenine targets an inflammatory pathway linked to diabetes and colorectal cancer
Hupehenine bound three proteins in an inflammation-linked pathway, reduced colorectal cancer cell phenotypes and shifted macrophage markers in a laboratory ...
Tubocapsenolide A Disrupts PLK1-Linked Damage Clearance in Oxaliplatin-Resistant Colorectal Cancer
A preclinical study finds that tubocapsenolide A inhibits PLK1, disrupting ESCRT-mediated damage clearance and restoring oxaliplatin sensitivity in resistant colorectal ...
Computational study prioritizes two benzohydrazide derivatives for EGFR testing
A computational and synthesis study prioritized benzohydrazide compounds 3d and 3f for experimental EGFR testing, while the lack of biological ...
Ketoprofen–thiazolidinone hybrids reduce inflammation in mouse paw edema
A study of synthesized ketoprofen–thiazolidin-4-one hybrids found that AR3 reduced mouse paw edema more consistently than ketoprofen at later time ...
Robots and Light Power KAIST’s Round-the-Clock Unmanned Drug Synthesis Platform
KAIST chemists have built an automated platform that combines robots, continuous-flow chemistry and visible light to synthesize drug candidate compounds ...
AI-Designed Molecules Show Promise as Host-Directed Antiviral Hits Against DHPS
Korea University researchers used benchmarked AI models to design small-molecule fragments that experimentally inhibited the human enzyme DHPS, a host ...
New Dung Fungus From Kenya Yields Novel Alkaloid With Antibacterial and Anticancer Potential
A newly described coprophilous fungus from Kenyan cow dung, Schizothecium keniense, produces the novel alkaloid pyrrospirone Z and other decahydrofluorene ...
New Soil Fungus Garciamycella chlamydospora Yields Rare Antifungal Papulacandins
A newly described soil fungus from the Netherlands, Garciamycella chlamydospora, founds a new sordarialean genus and produces rare papulacandin antifungals, ...
Fungus hiding on a rare Spanish plant yields potent new anticancer molecule
Deep in the arid zones of Andalusia, a microscopic fungus living quietly on the surface of an endemic plant has ...
AI Model Predicts Stable Molecular Forms to Sharpen Drug Discovery
Tautomerism occupies a curious position in chemistry: it is conceptually simple, involving nothing more than the relocation of a single ...
How Metagenomics and Metabolomics Are Joining Forces to Find New Antibiotics
A new review in Frontiers in Chemical Biology outlines how combining metagenomics and metabolomics can link microbial genomes to bioactive ...
New Combretastatin A-4 Stilbene Derivatives Profiled for Lipophilicity by Chromatography and Computation
Researchers profiled thirty-one novel combretastatin A-4 stilbene derivatives across five chromatographic systems and computational models, finding silica-based methanol systems best ...
POPULAR NEWS
-
Australian Stakeholders Largely Support Statutory Registration for Non-Registered Health Professions
-
Kalman Filter Improves Traction Force Microscopy Accuracy
-
Trimetallic Oxide Coating Yields Flexible Supercapacitor with 86% Retention
-
Recurrent Tongue Bleeding Treated in Woman With Hereditary Hemorrhagic Telangiectasia