Cells juggle two routes to make DNA building blocks, review finds
A Nature Metabolism review examines how cells balance de novo synthesis and salvage of nucleotides across tissues, immunity and cancer.
Tag: DNA replication
NAT10 enzyme adds ketone-derived tag to histones to speed DNA replication
A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...
CDK1 acts as a sensitive regulator of embryonic muscle growth in goats
A study of goat embryos identifies CDK1 as a hub gene whose moderate expression promotes muscle satellite cell proliferation, while ...
Cohesin reorganizes stressed DNA replication sites to protect genome stability
An experimental cell study finds that cohesin rapidly reorganizes stressed DNA replication sites and suppresses an error-prone restart pathway, helping ...
ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer
A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why ...
Fungal enzyme RTT109 proves essential for inheriting silenced chromatin
A new study in Neurospora crassa shows that the replication-linked histone acetyltransferase RTT109, acting independently of its known product H3K56 ...
Revolutionary Cryo-Electron Microscopy Unlocks Secrets of DNA Replication and Illuminates New Cancer Treatment Targets
Every day, our bodies engage in a remarkable process of cellular division, where billions of cells are replaced to ensure ...
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