Marsupial DNA Repair Gene MLH1 Retains Functional Retrocopies Across Multiple Lineages
Scientists have discovered that marsupials maintain functional, expressed retrocopies of the essential DNA repair gene MLH1 to compensate for parent-of-origin ...
Tag: DNA mismatch repair
Gene Therapy Halves Key DNA Repair Signal in Primate Brains, Model Predicts Slower Huntington’s Progression
A new study combines a computational model of CAG repeat instability with preclinical testing of an AAV-delivered microRNA that reduced ...
Genome Survey Confirms NucS and MutS-MutL Repair Systems Rarely Share the Same Microbe
A large-scale reanalysis of 23,435 prokaryotic reference genomes confirms that complete NucS and canonical MutS-MutL mismatch repair systems remain largely ...
RNA Cap Modification Emerges as a Switch That Governs Tumor Response to Radiotherapy
A new study shows that the RNA cap-modifying enzyme PCIF1 drives tumor growth and radioresistance, and that removing its m6Am ...
Defective DNA Repair Linked to Nectin-4 in UTUC
Recent advancements in cancer research have illuminated the role of DNA mismatch repair mechanisms and specific tumor markers, leading to ...
