Tag: cryo-electron microscopy

VIB and Ghent University researchers have revealed the molecular mechanism of IL-36 receptor activation, explaining how it triggers inflammation and ...

Cryo-electron microscopy structures of the cyanobacterial ChlG2HliD2 complex uncover how chlorophyll synthase coordinates substrate entry, catalysis, and photoprotective pigment binding ...

A structure-guided bivalent vaccine candidate stabilizes the prefusion respiratory syncytial virus fusion protein without exogenous disulfides, eliciting durable neutralizing antibodies ...

A new Nature study shows that the Andes virus spike captures the PCDH1 receptor through a deep central pocket that ...

The NIH has awarded $16.4 million over five years to a new multi-institution U19 center led by Scripps Research to ...

Cryo-EM and functional assays show that the JN.4-specific A475V substitution remodels the SARS-CoV-2 RBD large loop and reduces ACE2-binding affinity ...

Penn State researchers found that cancer-linked BRD4 can bind nucleosomes through both DNA contacts and recognition of modified histones, challenging ...

A near-atomic-resolution structure shows how a recessed pocket assembled from four hantavirus glycoproteins recognizes protocadherin-1 and how two distinct classes ...

Cryo-electron microscopy and single-molecule experiments show how phosphorylated M18BP1 relieves condensin II autoinhibition, enabling stable DNA binding and compaction in ...

Cryo-electron microscopy of porcine neutralizing antibodies bound to foot-and-mouth disease virus reveals how mutations on VP1 and VP3 drive antigenic ...

Cryo-electron microscopy structures of the Anopheles stephensi IR8a-IR75k receptor complex reveal how carboxylic acid odorants are recognized and how binding ...

Scientists have engineered a tetravalent nanobody agonist that harnesses differential TYK2 dependence and receptor abundance to deliver IL-10's anti-inflammatory power ...

New structural and biochemical analyses of the hepatitis C virus E2 glycoprotein show that germline-reverted broadly neutralizing antibodies recognize the ...

Researchers have discovered a bacterial antiviral defense system, DRT10, that synthesizes tandem-repeat DNA through a telomerase-like mechanism, revealing an evolutionary ...

Saint Louis University researchers have revealed an unexpected nitrogenase supercomplex in an ancient methanogen, a structural discovery that could transform ...

Researchers have resolved 76 coexisting conformers of the RNase P ribozyme at near-atomic resolution, revealing that catalysis arises from dynamic ...

Cryo-electron microscopy structures of the complete Lpt bridge show that a single transmembrane helix of LptC acts as a substrate-responsive ...

Researchers using cryo-electron microscopy have discovered that methanogen nitrogenase forms an inactive protein supercomplex that acts as a molecular off ...

Cryo-electron microscopy structures of human spliceosomes reveal the sequential roles of the helicases Aquarius, DHX15 and DHX35, together with newly ...

A new cryo-EM and biophysical study shows that removing the N153 glycan from dengue virus 2 exposes previously hidden epitopes, ...