Increased CSF PKR Activation in Alzheimer’s Disease Is Associated with APOE4 Genotype
A new study using SIMOA assays finds that elevated CSF phosphorylated PKR levels in Alzheimer’s disease are associated with APOE4 ...
Tag: Cognitive Decline
Younger Alzheimer’s patients carry heavier, faster-spreading tau burden, PET study finds
PET imaging of 601 people showed that early-onset Alzheimer's disease involves more severe tau accumulation that rises faster across wider ...
Frequent Anxiety Linked to Lower Cognitive Scores in Alzheimer’s Disease Study
An analysis of the Alzheimer’s Disease Neuroimaging Initiative found that frequent anxiety is strongly associated with lower global cognitive scores, ...
Erectile dysfunction may precede rare genetic brain disease by years, case series suggests
A retrospective case series of four male patients found that unexplained erectile dysfunction was the earliest symptom of NOTCH2NLC-related neuronal ...
NIH Awards $1M Grant to Study Sleep, Inflammation, and Dementia Risk
A five-year NIH grant will support research examining how sleep health, lipid-derived inflammatory mediators, and neighborhood conditions influence cognitive decline ...
Research report: Delayed associative memory and recall error patterns in mild cognitive impairment: discriminant capacity of the Italian face-name association test
Researchers published a study in GeroScience in October 2026 evaluating the diagnostic utility of the Italian Face-Name Association Test (ItFNAT) ...
Edible Plant Extracts Mitigate Cellular Ageing and Cognitive Declines in Mice
Researchers found that ethanol extracts and flavone glycosides from Dicliptera chinensis reduced cellular senescence markers in neuroblastoma cells and improved ...
Blood tau test rivals autopsy findings in predicting Alzheimer’s symptoms
A blood test for tau protein fragments predicted Alzheimer's cognitive symptoms nearly as accurately as autopsy-confirmed brain pathology in a ...
Rare SORL1 variants shape a typical Alzheimer’s profile, with hints of faster decline in one genetic subgroup
A study of 1,546 patients with biomarker-confirmed symptomatic Alzheimer's disease found that 35 carriers of rare high-risk SORL1 variants showed ...
Blood proteins track Parkinson’s worsening over time
Repeated serum proteomics in 166 Parkinson's patients identified six protein-clinical associations linked to clinical worsening across motor, cognitive, and treatment ...
Light Therapy Clears Brain Waste in Young and Middle-Aged Mice but Fails in Old Ones
A mouse study finds that photobiomodulation improves learning and amyloid beta clearance in young and middle-aged animals, but not in ...
Inflammation marker CRP/albumin ratio linked to mild cognitive impairment in older adults
A cross-sectional study of 300 adults aged 65 and older found that a higher CRP/albumin ratio was independently associated with ...
Higher neuroplasticity marker linked to faster cognitive decline in women only
A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive ...
Visuo-spatial attention shapes how reading declines in healthy aging
A study of 120 healthy older adults found that general cognitive functions mediate age-related reading decline, while visuo-spatial attention moderates ...
Herpes zoster linked to faster cognitive decline in older adults
A cohort study of 16,324 older adults found incident herpes zoster associated with faster annual decline in global cognitive scores, ...
Hobbies Linked to Years of Extra Cognitive Health After Age 50
A four-cohort study of over 123,000 adults aged 50 and older across 31 countries links hobby engagement to lower cognitive ...
Neuropsychiatric Symptoms in Alzheimer’s Disease Linked to Amyloid and Heat Shock Proteins
A cross-sectional ADNI study of 713 participants links neuropsychiatric symptoms to lower CSF amyloid-β42 and identifies heat shock protein pathways ...
Diabetes Dementia Risk Hinges on APOE ε4 and Alpha-Klotho, Review Argues
A narrative review proposes that APOE ε4 amplifies diabetes-related cognitive decline across metabolic, vascular, and neurodegenerative layers, while α-Klotho may ...
Walking Time Emerges as Early Warning Signal for Combined Cognitive and Physical Decline in Older Adults
A multinational cohort study using temporal deep learning identified deteriorating walking time as the strongest predictor of dual cognitive-physical decline ...
Blood Test for Early Alzheimer’s Detection Stays Stable Across Storage Conditions
A prospective observational study found that plasma pTau181 measured with the Elecsys Phospho-Tau (181P) immunoassay remained stable across varied sample ...
