LncPRESS1 Drives Breast Cancer Progression and Cisplatin Resistance
A new study in Cell Division reveals that the long noncoding RNA LncPRESS1 promotes breast cancer progression and cisplatin resistance ...
Tag: chemotherapy
Transformed Blasts in TP53-Mutated Leukemia Mimic Malignant Histiocytic Neoplasms
A case report identifies a deceptive diagnostic pitfall where TP53-mutated acute myeloid leukemia blasts mimic mature malignant histiocytic neoplasms following ...
Iron Transport Genes Predict Cancer Survival and Chemotherapy Response
Researchers published a study in BioData Mining demonstrating that the expression levels of three specific iron transport genes can predict ...
Review Evaluates Nanocarrier Co-Delivery Strategies for Colorectal Cancer Combination Therapy
A scientific review critically evaluates how nanocarrier-based co-delivery platforms coordinate multi-agent chemotherapy, targeted ligands, and energy-based therapies for colorectal cancer ...
Carvedilol Fails to Prevent Anthracycline-Induced Cardiotoxicity in Meta-Analysis
A systematic review of nine randomized trials found that carvedilol does not significantly preserve left ventricular ejection fraction in adult ...
New Spider Silk Particles Improve Drug Loading Stability
Researchers developed DM4R2 spider silk particles with improved stability and drug loading capacity for chemotherapeutic and protein drug delivery.
Liposomal Eribulin Shows First-Line Antitumor Activity in Advanced HER2-Negative Breast Cancer
A phase 1 expansion cohort demonstrated meaningful antitumor responses and manageable safety for liposomal eribulin as first-line chemotherapy in metastatic ...
Adaptive Lenalidomide Intensification Evaluated Following CyBorD Induction in Multiple Myeloma
A prospective clinical trial found response-adapted lenalidomide and dexamethasone intensification before transplantation did not surpass historical complete response benchmarks.
Adding Chemotherapy to First-Line EGFR-Targeted Therapy Extends Survival in Advanced Lung Cancer, Meta-Analysis Finds
A meta-analysis of ten trials in 2162 patients found that first-line EGFR-TKI plus chemotherapy improved progression-free and overall survival in ...
Targeting DNA Repair Genes Overcomes Cisplatin Resistance in Colon Cancer Organoids
Inhibition of specific DNA repair pathways restores cisplatin sensitivity and enhances cell death in TP53-deficient colon cancer organoids.
Phase 2 Trial of Neoadjuvant Durvalumab and Tremelimumab with Chemotherapy Does Not Meet Primary Endpoint in Advanced High-Grade Serous Ovarian Cancer
A phase 2 trial found that adding immunotherapy to chemotherapy did not improve the primary efficacy endpoint in advanced ovarian ...
Review Maps Gut Metabolites to Chemo-Related Cognitive Decline
A new review in Frontiers in Pharmacology evaluates how microbial metabolites may mediate chemotherapy-induced cognitive impairment, providing a framework for ...
Low Vitamin D Linked to Chemotherapy Neuropathy Risk
A systematic review suggests low vitamin D status may be associated with increased risk of chemotherapy-induced peripheral neuropathy, though evidence ...
Ovarian Suppression May Not Benefit Premenopausal Breast Cancer Patients Over 40
A retrospective cohort study found that ovarian function suppression after chemotherapy did not significantly improve survival outcomes in premenopausal breast ...
Math Model Shows CAR T-Cell Therapy Outperforms Chemotherapy Against Leukemia
A new mathematical model comparing chemotherapy and CAR T-cell therapy for leukemia finds that simulated T-cell infusion produces a stronger ...
Platelet-derived microparticles may drive acute myeloid leukemia progression and inspire nanoparticle drug delivery
A new review examines how platelet-derived microparticles may worsen acute myeloid leukemia by transferring molecular cargo to cancer cells, and ...
Nisin-Coated Lipid Nanoparticles Boost Cisplatin’s Cancer-Killing Power in Cell Studies
Solid lipid nanoparticles co-delivering nisin and cisplatin showed enhanced cytotoxicity against A431 and MCF-7 cancer cells in vitro, triggering intrinsic ...
Whole-Genome Sequencing Explores Why Low-Risk Patients Develop Bleomycin Lung Injury
Whole-genome sequencing of 21 predominantly low-risk patients with bleomycin-induced pneumonitis identified biologically plausible candidate variants but no single unifying genetic ...
Exercise Shows Early Safety Signals During Triple-Negative Breast Cancer Chemotherapy
A scoping review proposes that exercise adaptations may align with triple-negative breast cancer biology, citing preliminary safety and feasibility evidence ...
Blood markers shift with chemotherapy in Ghanaian breast cancer patients
A cross-sectional study of 120 Ghanaian participants found that chemotherapy-experienced breast cancer patients showed significantly lower red blood cell, haemoglobin, ...
