Tag: chemoresistance

A new Cellular Oncology study reports that the tumor suppressor TNFAIP3 restrains lactylation-linked DNA damage repair and increases ovarian cancer ...

Researchers report that lactate-driven lactylation of the DNA repair protein RPA1 at lysine 167, catalyzed by KAT8 after ATM phosphorylation, ...

A gemcitabine-modified tumor-suppressor microRNA called Gem-miR-15a overcame 5-FU and oxaliplatin resistance in preclinical colorectal cancer models with low-nanomolar potency and ...

Engineered ovarian cancer cell models carrying an activating NRAS mutation showed heightened sensitivity to the MEK inhibitor trametinib, suggesting a ...

A preclinical study reports that ginsenoside RK3 suppressed osteosarcoma growth in cells and mouse xenografts by downregulating PRMT5, promoting GPX4 ...

A review finds that miR-125b, miR-375 and miR-451 are linked to breast cancer chemoresistance through distinct, context-dependent mechanisms that require ...

New research from Montreal reveals that the sorting receptor SORT1 links lipid remodeling, stemness and drug resistance in 3D glioblastoma ...

A new review argues that proteases drive chemoresistance through drug transport, matrix remodeling, and cell death signaling, and that precision-targeted ...

A single-cell transcriptomic analysis of paired diagnosis and relapse samples identifies chemoresistant cell populations that, combined with cytogenetics and measurable ...

A comprehensive narrative review synthesizes evidence that plant-derived phytochemicals modulate apoptosis, angiogenesis, HPV oncogenes, and epigenetic regulation across gynecological cancers, ...

A new study shows that the microRNA-197-3p molecule, which is depleted in ovarian cancer, directly suppresses the collagen protein COL4A6 ...

One of the most stubborn obstacles in treating acute myeloid leukaemia is not the leukaemia cell itself but the neighbourhood ...

A new review highlights how chitosan-based nanoparticles can deliver drugs precisely, overcome chemoresistance, and combine photothermal, photodynamic, and immunotherapeutic strategies ...

New research shows that the surface protein CD7 actively drives chemotherapy resistance in acute myeloid leukemia by amplifying NF-κB signaling, ...

Researchers at Nanjing Medical University report that the m6A-stabilized circular RNA circLPAR3 suppresses ferroptosis through the PCBP2/CHAC1 axis, driving docetaxel ...

New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...

Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...

A new Cell Death Discovery study shows that the two strands of the pre-miR-16-1 microRNA duplex can cooperatively suppress both ...

New research shows that triple-negative breast cancer cells rely on shared DNA damage tolerance enzymes such as POLζ and CHK1 ...

A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...