Tag: chemoresistance

Researchers found that PAQR4 stabilizes NRF2 to inhibit ferroptosis and promote cisplatin resistance in bladder cancer models.

A comprehensive review analyzes how platinum chemotherapy has evolved across three generations to treat cervical cancer alongside emerging nanotechnology systems ...

Targeting the chemokine receptor CCR5 with maraviroc suppresses M2 macrophage polarization and restores bortezomib sensitivity in multiple myeloma models.

A case–control study reveals that elevated CD79B protein expression independently predicts poor therapeutic response to standard R-CHOP immunochemotherapy in non-germinal ...

High expression of MCOLN2 drives Adriamycin resistance in breast cancer by destabilizing mTOR to promote autophagy, according to laboratory and ...

A laboratory study demonstrates that combining low-dose metformin with doxorubicin suppresses epithelial-to-mesenchymal transition and enhances antiproliferative effects in HepG2 liver ...

A review indicates that exosome-mediated microRNA transfer regulates apoptotic signaling pathways and drives chemoresistance in ovarian cancer.

A new study identifies a six-lncRNA signature that predicts osteosarcoma survival and reveals that LINC01976 drives cisplatin resistance through a ...

A scientific review details how Fusobacterium nucleatum drives colorectal cancer progression and chemoresistance while paradoxically sensitizing select tumors to immunotherapy.

Researchers discover that inhibiting the splicing regulator SRRM1 activates ferroptosis to overcome gemcitabine resistance in pancreatic cancer models.

Researchers discover that the enzyme DPP9 promotes temozolomide resistance in glioma by controlling RFWD3 nuclear localization and sustaining RPA1 stability.

A new study identifies andrographolide as a compound that disrupts SDHA–SDHAF4 assembly to promote ferroptosis and enhance doxorubicin sensitivity in ...

A single-cell transcriptomics study reveals that conserved fallopian tube epithelial programs drive chemoresistance and treatment response heterogeneity in ovarian high-grade ...

A review in Cellular Oncology synthesizes evidence on how primary cilia gain and loss orchestrate therapeutic resistance and metastasis across ...

Researchers have identified an oncogenic SLC39A14-PIWIL2 fusion gene in hepatocellular carcinoma and engineered synthetic decoy peptides that disrupt downstream protein ...

Laboratory experiments show collagen type I coating inhibits pancreatic cancer cell growth while fibronectin supports it, and both reduce sensitivity ...

A new review describes how the long non-coding RNA MALAT1 drives leukemia cell survival, proliferation and chemotherapy resistance in acute ...

A new hypothesis-generating review proposes that the adult liver cancer blood marker AKR1B10 may also hold diagnostic value for pediatric ...

A systematic review finds that nanoparticle and liposome delivery systems consistently improve resveratrol's stability and tumor uptake in preclinical models, ...

A combination of low-dose metformin and valproic acid reprograms the metabolism of drug-tolerant persister cells in gastric and liver cancer ...