Prehabilitation Exercise Shows Mixed Results Before Cellular Therapy
A systematic review of 12 studies finds that pre-treatment exercise generally improves physical function but yields mixed results for strength ...
Tag: CAR-T therapy
Extramedullary relapse linked to poorer survival after CAR-T in myeloma
A retrospective study of 40 Chinese patients found that extramedullary relapse after BCMA-directed CAR-T therapy is associated with significantly inferior ...
Allogeneic Transplant After Bispecific Antibody Salvage Shows Promise in Relapsed High-Grade B-Cell Lymphoma
Two case reports suggest glofitamab followed by allogeneic stem cell transplantation can sustain remissions in relapsed or refractory high-grade B-cell ...
Loop CAR-T Cells Target Heterogeneous Leukemia Antigens
New loop-structured CAR-T cells targeting CD38 and CD123 show enhanced activity against heterogeneous acute myeloid leukemia in preclinical models.
DUSP4 protein keeps cancer-killing T cells active against colorectal tumours
NUS Medicine researchers found that the protein DUSP4 helps CD8+ T cells retain their cancer-killing function and that boosting its ...
CLL treatment shifts toward fixed-duration and MRD-guided targeted regimens
A new review describes how chronic lymphocytic leukemia treatment has shifted from chemoimmunotherapy to targeted, fixed-duration, and MRD-guided regimens guided ...
CAR-T Therapy for Brain Tumors Shows Early Promise and Persistent Barriers
A conference correspondence summarizing 12 clinical and translational abstracts on next-generation CAR-T therapy for malignant brain tumors, reporting early feasibility ...
CAR-T Cytokine Release Syndrome Shows Distinct Symptom Profiles by Timing, Severity and Duration
A retrospective study of 128 multiple myeloma patients links distinct CRS symptom profiles to onset timing, severity and duration after ...
Two-Week Risk Score Identifies Low-Infection Group After CAR-T Therapy
A retrospective registry analysis of 3,302 adults with large B-cell lymphoma found that machine-learning models using information available by Day ...
In vivo CAR-T therapy aims to turn bespoke living drugs into universal genetic medicines
A new review charts how in vivo CAR-T engineering could transform customized living drugs into scalable, off-the-shelf genetic medicines.
A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
Donor-Derived CD19 CAR-T Cells Deliver Lasting Remissions in Leukemia Patients After Transplant Failure
A Chinese clinical study reports that donor-derived anti-CD19 CAR-T cells achieved complete remissions in 13 of 14 patients whose B-cell ...
Expert Panel Maps the Hidden Variables That Could Skew CAR-T Comparisons in Lymphoma
A two-round expert elicitation among German and Austrian hematologists has produced a consensus list of prognostic factors and treatment-effect modifiers ...
Blood Cancer Risk After CAR-T and Stem Cell Transplants: Systematic Review Maps Latency and Clonal Drivers
A systematic review of nine studies finds that therapy-related myeloid neoplasms after CAR-T therapy emerge earlier and carry worse survival ...
New Wave of Targeted and Immune Therapies Reshapes Marginal Zone Lymphoma Care
A new review in Annals of Hematology details how molecular profiling and a growing arsenal of targeted and immune-based therapies ...
Bystander T Cells Boost the Antitumor Efficacy of Bispecific Antibodies
Researchers are continuing to make strides in the field of immunotherapy, particularly focusing on the treatment of relapsed or refractory ...
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